来自花脸马兜铃的新型细胞毒性马兜铃内酰胺类化合物。

New cytotoxic aristolactams from Pararistolochia flos-avis.

作者信息

Sun N J, Antoun M, Chang C J, Cassady J M

机构信息

Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.

出版信息

J Nat Prod. 1987 Sep-Oct;50(5):843-6. doi: 10.1021/np50053a011.

DOI:10.1021/np50053a011

PMID:3437282

Abstract

Two new aristolactams, aristolactam-FI [1] and -FII [2], were isolated from active extracts of Pararistolochia flos-avis. Their structures were elucidated on the basis of nmr, ms, uv, and ir spectral data. Aristolactam-I [3] and -AII [4] were also isolated from this plant. Aristolactam-AII showed cytotoxicity against PS and KB cells in culture.

摘要

从花面马兜铃的活性提取物中分离出两种新的马兜铃内酰胺，即马兜铃内酰胺 - FI [1] 和 - FII [2]。根据核磁共振、质谱、紫外和红外光谱数据阐明了它们的结构。还从该植物中分离出马兜铃内酰胺 - I [3] 和 - AII [4]。马兜铃内酰胺 - AII在培养中对PS和KB细胞显示出细胞毒性。