Konoshima T, Lee K H
J Nat Prod. 1986 Jul-Aug;49(4):650-6. doi: 10.1021/np50046a015.
Two cytotoxic sapogenols, the new hippocaesculin (1) and the known barringtogenol-C 21-angelate (2), were isolated from the acid hydrolysis product of a crude saponin fraction that was obtained from the fruits of Aesculus hippocastanum. The structures of 1 and 2 were determined from their chemical transformations and spectral data. Compound 1 is either 21-O-angeloyl, 22-O-tigloyl R1-barrigenol, or 21-O-tigloyl, 22-O-angeloyl R1-barrigenol.
从欧洲七叶树果实中获得的粗皂苷部分的酸水解产物中分离出两种具有细胞毒性的皂草配基，即新的马栗皂苷元（1）和已知的21-当归酰巴豆苷元-C（2）。通过化学转化和光谱数据确定了1和2的结构。化合物1要么是21-O-当归酰基、22-O-惕各酰基R1-巴豆苷元，要么是21-O-惕各酰基、22-O-当归酰基R1-巴豆苷元。
