Energy Research Centre, Panjab University, Chandigarh 160014, India.
University Institute of Pharmaceutical Sciences, UGC-Centre of Advanced Studies, Panjab University, Chandigarh 160014, India.
Crit Rev Ther Drug Carrier Syst. 2021;38(5):27-51. doi: 10.1615/CritRevTherDrugCarrierSyst.2021033808.
This article aims to provide a comprehensive review of Cissus quadrangularis (CQ), which is a traditional medicinal herb and has a potential osteoprotective effect. CQ is a perennial climber of family Vitaceae that is commonly found in the hotter parts of India. It is most widely used in India for improving bone health and is well known as "hadjod." It shows an anti-osteoporotic effect through different pathways mechanisms. It is natural matrices of excellence with proven bioactivity. Several cell line and animal studies demonstrated its protective nature against many diseases such as osteoporosis, arthritis, gastric ulcers etc. This review also highlights the phytochemicals identified to the date and related pharmacological applications. The discussion has also expanded to its oral formulations, which has been proven for its efficacy practically. However, the scientific information of CQ is not in the proper documentation for reference, and so availability of scientific knowledge of this climber is limited. Therefore, this review might be provided a platform to those who will be interested in studying further this herb, either for analyzing phytochemical profiling or its anti-osteoporotic usage. This is a crucial platform as several productive results have been reported on this herb, which likely to be beneficial for new drug discovery in future. Here we also discuss the bone remodeling and related factors influenced by the intake of CQ.
本文旨在对筋骨草（CQ）进行全面综述，筋骨草是一种传统药用植物，具有潜在的护骨作用。CQ 是旋花科的一种多年生攀援植物，常见于印度较热的地区。它在印度被广泛用于改善骨骼健康，被称为“hadjod”。它通过不同的途径机制表现出抗骨质疏松作用。它是具有优良天然基质和已证明的生物活性的物质。一些细胞系和动物研究表明，它对骨质疏松症、关节炎、胃溃疡等许多疾病具有保护作用。本综述还强调了迄今为止已鉴定出的植物化学物质及其相关的药理应用。讨论还扩展到了它的口服制剂，这些制剂在实践中已被证明具有疗效。然而，CQ 的科学信息没有得到适当的记录，因此这种攀援植物的科学知识有限。因此，本综述可能为那些有兴趣进一步研究这种草药的人提供一个平台，无论是分析植物化学特征还是其抗骨质疏松作用。这是一个至关重要的平台，因为已经有报道称这种草药有许多富有成效的结果，这可能对未来的新药发现有益。在这里，我们还讨论了骨重塑和相关因素，这些因素受 CQ 摄入的影响。
