H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist-Dhule, 425 405, Maharashtra, India.
School of Pharmacy and Technology Management, SVKM's NMIMS, Shirpur, Dist-Dhule, 425 405, Maharashtra, India.
J Ethnopharmacol. 2021 Oct 28;279:114355. doi: 10.1016/j.jep.2021.114355. Epub 2021 Jun 25.
Cissus quadrangularis L. is a perennial herb of the Vitaceae family and is utilized comprehensively as a medicinal herb in most tropical regions by various names. This herb is documented to possess a wide-ranging ethnomedicinal uses in malaria, fever, epilepsy, gout, piles, skin diseases, colic, etc. AIM OF THE REVIEW: A organized summary of the botany, traditional uses, phytochemistry, pharmacology, toxicology, available marketed formulations and filed patents were presented to explore the future therapeutic potential and scientific potential of this herb.
For a review of the literature, various databases were searched, including PubMed, EMBASE, and Scopus etc. From, total 408 records of this herb, we have screened 155 articles consist of desired information and available as full text. Present manuscript is structured from comprehensive information on this herb from screened 155 records. Plant taxonomy was confirmed to the database "The Plant List".
Phytochemical assessment as a whole indicated the presence of flavonoids, triterpenoids, alkaloids, saponins, iridoids, stilbenes, vitamins, steroids, and glycosides. A toxicity study revealed that its LD value is above 3000 mg/kg in animals indicating its safety. A variety of pharmacological studies of aerial parts of this herb by different extracts have demonstrated analgesic, anti-inflammatory, anticonvulsant, antimicrobial, anticancer, anti-osteoporotic activity and other bone-related disorders to justify its name as Hadjod. Still, the herb has been utilized in clinical practice and several patents were filed in India and US for its antiosteoporotic property.
The studies on Cissus quadrangularis Linn. are extensive, but gaps still remain. The molecular mechanism, structure-activity relationship, potential synergistic and antagonistic effects of these components needs to be further elucidated. These findings suggest the need for further research on this herb for the management of several other chronic ailments.
菱叶崖爬藤是葡萄科的一种多年生藤本植物，在大多数热带地区，它被广泛用作草药，并以各种名称使用。该草药被记录具有广泛的民间医学用途，可用于治疗疟疾、发热、癫痫、痛风、痔疮、皮肤病、绞痛等。
本文对该植物的植物学、传统用途、植物化学、药理学、毒理学、市售制剂和已申请专利进行了系统总结，以探讨该草药的未来治疗潜力和科学潜力。
为了进行文献综述，我们检索了包括 PubMed、EMBASE 和 Scopus 在内的各种数据库。从总共 408 条关于该草药的记录中，我们筛选出了 155 篇包含所需信息且可提供全文的文章。本文是根据从筛选出的 155 篇记录中获得的关于该草药的综合信息构建的。植物分类学已被确认为数据库“植物名录”。
整体而言，植物化学评估表明存在黄酮类、三萜类、生物碱、皂苷、环烯醚萜类、芪类、维生素、甾体和糖苷。一项毒性研究表明，其在动物体内的 LD 值大于 3000mg/kg，表明其安全性。对该草药地上部分的各种药理学研究表明，其不同提取物具有镇痛、抗炎、抗惊厥、抗菌、抗癌、抗骨质疏松活性和其他与骨骼相关的疾病，这证明了它作为 Hadjod 的名称。尽管如此，该草药仍在临床实践中使用，并且在印度和美国提交了几项专利，以证明其抗骨质疏松特性。
对菱叶崖爬藤的研究很广泛，但仍存在差距。这些成分的分子机制、构效关系、潜在协同和拮抗作用仍需进一步阐明。这些发现表明，需要进一步研究该草药，以治疗其他几种慢性疾病。
