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2
The primary outcome measure and its importance in clinical trials.主要结局指标及其在临床试验中的重要性。
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3
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J Epidemiol Community Health. 2011 May;65(5):392-5. doi: 10.1136/jech.2010.119933. Epub 2010 Oct 14.
4
Reader's guide to critical appraisal of cohort studies: 2. Assessing potential for confounding.队列研究的批判性评价读者指南:2. 评估混杂因素的可能性。
BMJ. 2005 Apr 23;330(7497):960-2. doi: 10.1136/bmj.330.7497.960.
5
Confronting the confounders: the meaning, detection, and treatment of confounders in research.应对混杂因素:研究中混杂因素的含义、检测与处理
Can J Psychiatry. 1999 Mar;44(2):175-9. doi: 10.1177/070674379904400209.

临床研究概念化与设计中变量分类及操作化的学生指南:第1部分

A Student's Guide to the Classification and Operationalization of Variables in the Conceptualization and Design of a Clinical Study: Part 1.

作者信息

Andrade Chittaranjan

机构信息

Dept. of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

出版信息

Indian J Psychol Med. 2021 Mar;43(2):177-179. doi: 10.1177/0253717621994334. Epub 2021 Feb 26.

DOI:10.1177/0253717621994334
PMID:34376897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8313451/
Abstract

Students without prior research experience may not know how to conceptualize and design a study. This article explains how an understanding of the classification and operationalization of variables is the key to the process. Variables describe aspects of the sample that is under study; they are so called because they vary in value from subject to subject in the sample. Variables may be independent or dependent. Independent variables influence the value of other variables; dependent variables are influenced in value by other variables. A hypothesis states an expected relationship between variables. A significant relationship between an independent and dependent variable does not prove cause and effect; the relationship may partly or wholly be explained by one or more confounding variables. Variables need to be operationalized; that is, defined in a way that permits their accurate measurement. These and other concepts are explained with the help of clinically relevant examples.

摘要

没有先前研究经验的学生可能不知道如何构思和设计一项研究。本文解释了对变量的分类和操作化的理解是这一过程的关键。变量描述了所研究样本的各个方面;之所以这样称呼它们,是因为它们在样本中的不同个体之间具有不同的值。变量可以是自变量或因变量。自变量影响其他变量的值;因变量的值受其他变量的影响。一个假设陈述了变量之间的预期关系。自变量和因变量之间的显著关系并不证明因果关系;这种关系可能部分或全部由一个或多个混杂变量来解释。变量需要进行操作化;也就是说,要以允许对其进行准确测量的方式来定义。这些以及其他概念将借助临床相关示例进行解释。