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组蛋白mRNA 3'端的茎环结构对于组蛋白mRNA稳定性的调控是必需且充分的。

The stem-loop structure at the 3' end of histone mRNA is necessary and sufficient for regulation of histone mRNA stability.

作者信息

Pandey N B, Marzluff W F

机构信息

Department of Chemistry, Florida State University, Tallahassee 32306.

出版信息

Mol Cell Biol. 1987 Dec;7(12):4557-9. doi: 10.1128/mcb.7.12.4557-4559.1987.

DOI:10.1128/mcb.7.12.4557-4559.1987
PMID:3437896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC368142/
Abstract

Chimeric genes were made by fusing mouse histone genes with a human alpha-globin gene. The genes were introduced into mouse L cells and the stability of the chimeric mRNAs was measured when DNA synthesis was inhibited. An mRNA containing all the globin coding sequences and the last 30 nucleotides of the histone mRNA was degraded at the same rate as histone mRNA.

摘要

嵌合基因是通过将小鼠组蛋白基因与人α-珠蛋白基因融合而构建的。这些基因被导入小鼠L细胞中，并且在DNA合成被抑制时测量嵌合mRNA的稳定性。一种包含所有珠蛋白编码序列以及组蛋白mRNA最后30个核苷酸的mRNA，其降解速率与组蛋白mRNA相同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/368142/d80e158a5c7f/molcellb00084-0418-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/368142/d80e158a5c7f/molcellb00084-0418-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18f/368142/d80e158a5c7f/molcellb00084-0418-a.jpg

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本文引用的文献

1
The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication.人类α-珠蛋白假基因的结构及其与α-珠蛋白基因重复的关系。
Cell. 1980 Sep;21(2):537-44. doi: 10.1016/0092-8674(80)90491-2.
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Histone H5 messenger RNA is polyadenylated.组蛋白H5信使核糖核酸是聚腺苷酸化的。
Nature. 1980 Jan 31;283(5746):502-4. doi: 10.1038/283502a0.
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Rapid reversible changes in the rate of histone gene transcription and histone mRNA levels in mouse myeloma cells.小鼠骨髓瘤细胞中组蛋白基因转录速率和组蛋白mRNA水平的快速可逆变化。
组蛋白 mRNA 茎环的尿嘧啶酰化削弱了与 SLBP 的结合相互作用，同时保持与 3' hExo 的相互作用。
RNA Biol. 2023 Jan;20(1):469-481. doi: 10.1080/15476286.2023.2171760.
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Knockouts of TUT7 and 3'hExo show that they cooperate in histone mRNA maintenance and degradation.TUT7 和 3'hExo 的敲除表明它们在组蛋白 mRNA 的维持和降解中合作。
RNA. 2022 Nov;28(11):1519-1533. doi: 10.1261/rna.079233.122. Epub 2022 Aug 30.
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Human cytomegalovirus lytic infection inhibits replication-dependent histone synthesis and requires stem loop binding protein function.人类巨细胞病毒裂解感染抑制复制依赖性组蛋白合成，需要茎环结合蛋白功能。
Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2122174119. doi: 10.1073/pnas.2122174119. Epub 2022 Mar 28.
6
Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma.蛋白磷酸酶1调节亚基1A调控尤因肉瘤的细胞周期进程。
Oncotarget. 2020 May 12;11(19):1691-1704. doi: 10.18632/oncotarget.27571.
7
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UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond.在 RNA 衰变中处于前沿和中心位置：UPF1 在无意义介导的 mRNA 衰变及其他方面的作用。
RNA. 2019 Apr;25(4):407-422. doi: 10.1261/rna.070136.118. Epub 2019 Jan 17.
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Determining degradation intermediates and the pathway of 3' to 5' degradation of histone mRNA using high-throughput sequencing.利用高通量测序技术确定组蛋白 mRNA 3'到 5'降解的降解中间产物和途径。
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Regulation of histone mRNA production and stability in serum-stimulated mouse 3T6 fibroblasts.血清刺激的小鼠3T6成纤维细胞中组蛋白mRNA产生和稳定性的调控
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6
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10
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