组蛋白mRNA 3'端的茎环结构对于组蛋白mRNA稳定性的调控是必需且充分的。
The stem-loop structure at the 3' end of histone mRNA is necessary and sufficient for regulation of histone mRNA stability.
作者信息
Pandey N B, Marzluff W F
机构信息
Department of Chemistry, Florida State University, Tallahassee 32306.
出版信息
Mol Cell Biol. 1987 Dec;7(12):4557-9. doi: 10.1128/mcb.7.12.4557-4559.1987.
Abstract
Chimeric genes were made by fusing mouse histone genes with a human alpha-globin gene. The genes were introduced into mouse L cells and the stability of the chimeric mRNAs was measured when DNA synthesis was inhibited. An mRNA containing all the globin coding sequences and the last 30 nucleotides of the histone mRNA was degraded at the same rate as histone mRNA.
摘要
嵌合基因是通过将小鼠组蛋白基因与人α-珠蛋白基因融合而构建的。这些基因被导入小鼠L细胞中，并且在DNA合成被抑制时测量嵌合mRNA的稳定性。一种包含所有珠蛋白编码序列以及组蛋白mRNA最后30个核苷酸的mRNA，其降解速率与组蛋白mRNA相同。
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