Seo Eunhye, Lee Yesung, Mun Eunchan, Kim Dae Hoon, Jeong Youshik, Lee Jaehong, Jeong Jinsook, Lee Woncheol
Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Ann Occup Environ Med. 2022 Mar 14;34:e4. doi: 10.35371/aoem.2022.34.e4. eCollection 2022.
Long working hours are known to account for approximately one-third of the total expected work-related diseases, and much interest and research on long working hours have recently been conducted. Additionally, as the prevalence of prediabetes and the high-risk group for diabetes are increasing worldwide, interest in prediabetes is also rising. However, few studies have addressed the development of type 2 diabetes and long working hours in prediabetes. Therefore, the aim of this longitudinal study was to evaluate the relationship between long working hours and the development of diabetes in prediabetes.
We included 14,258 prediabetes participants with hemoglobinA1c (HbA1c) level of 5.7 to 6.4 in the Kangbuk Samsung Cohort Study. According to a self-reported questionnaire, we evaluated weekly working hours, which were categorized into 35-40, 41-52, and > 52 hours. Development of diabetes was defined as an HbA1c level ≥ 6.5%. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the development of diabetes were estimated using Cox proportional hazards analyses with weekly working 35-40 hours as the reference.
During a median follow-up of 3.0 years, 776 participants developed diabetes (incidence density, 1.66 per 100 person-years). Multivariable-adjusted HRs of development of diabetes for weekly working > 52 hours compared with working 35-40 hours were 2.00 (95% CI: 1.50-2.67). In subgroup analyses by age (< 40 years old, ≥ 40 years old), sex (men, women), and household income (< 6 million KRW, ≥ 6 million KRW), consistent and significant positive associations were observed in all groups.
In our large-scale longitudinal study, long working hours increases the risk of developing diabetes in prediabetes patients.
众所周知，长时间工作约占所有预期职业相关疾病的三分之一，近期人们对长时间工作产生了浓厚兴趣并开展了大量研究。此外，随着全球范围内糖尿病前期和糖尿病高危人群的患病率不断上升，对糖尿病前期的关注度也在增加。然而，很少有研究探讨糖尿病前期人群中2型糖尿病的发生与长时间工作之间的关系。因此，这项纵向研究的目的是评估长时间工作与糖尿病前期人群患糖尿病之间的关系。
在江北三星队列研究中，我们纳入了14258名糖化血红蛋白（HbA1c）水平为5.7至6.4的糖尿病前期参与者。根据一份自我报告问卷，我们评估了每周工作时长，并将其分为35 - 40小时、41 - 52小时和超过52小时。糖尿病的发生定义为HbA1c水平≥6.5%。以每周工作35 - 40小时为参照，使用Cox比例风险分析估计糖尿病发生的风险比（HR）和95%置信区间（CI）。
在中位随访3.0年期间，776名参与者患上了糖尿病（发病密度为每100人年1.66例）。与每周工作35 - 40小时相比，每周工作超过52小时的糖尿病发生多变量调整HR为2.00（95%CI：1.50 - 2.67）。在按年龄（<40岁、≥40岁）、性别（男性、女性）和家庭收入（<600万韩元、≥600万韩元）进行的亚组分析中，所有组均观察到一致且显著的正相关。
在我们的大规模纵向研究中，长时间工作会增加糖尿病前期患者患糖尿病的风险。
