Humanitas Clinical and Research Center IRCCS, Rozzano, Italy; Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charitè - Universitätsmedizin Berlin, Germany; Berlin Institute of Health, Berlin, Germany; Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Berlin, Germany.
Humanitas Clinical and Research Center IRCCS, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Rozzano, Italy; The William Harvey Research Institute, Queen Mary University of London, London, UK.
Trends Immunol. 2021 Sep;42(9):764-781. doi: 10.1016/j.it.2021.07.002. Epub 2021 Aug 9.
The membrane-spanning 4A (MS4A) family includes 18 members with a tetraspan structure in humans. They are differentially and selectively expressed in immunocompetent cells, such as B cells (CD20/MS4A1) and macrophages (MS4A4A), and associate with, and modulate the signaling activity of, different classes of immunoreceptor, including pattern recognition receptors (PRRs) and Ig receptors. Evidence from preclinical models and genetic evidence from humans suggest that members of the MS4A family have key roles in different pathological settings, including cancer, infectious diseases, and neurodegeneration. Therefore, MS4A family members might serve as candidate biomarkers and therapeutic targets for various conditions.
四跨膜结构域蛋白 4A（MS4A）家族包括人类中的 18 个成员，具有四跨膜结构。它们在免疫活性细胞中差异性和选择性表达，如 B 细胞（CD20/MS4A1）和巨噬细胞（MS4A4A），并与不同类别的免疫受体（包括模式识别受体（PRRs）和 Ig 受体）相互作用，调节其信号活性。临床前模型和人类遗传证据表明，MS4A 家族成员在不同的病理情况下发挥关键作用，包括癌症、传染病和神经退行性疾病。因此，MS4A 家族成员可能作为各种疾病的候选生物标志物和治疗靶点。
