Department of Pharmaceuticals, Affiliated Hospital of Yan'an University, Yan'an 716000, Shaanxi, China.
Contrast Media Mol Imaging. 2021 Jul 26;2021:9032017. doi: 10.1155/2021/9032017. eCollection 2021.
There was an investigation of the auxiliary role of convolutional neural network- (CNN-) based magnetic resonance imaging (MRI) image segmentation algorithm in MRI image-guided targeted drug therapy of doxorubicin nanomaterials so that the value of drug-controlled release in liver cancer patients was evaluated. In this study, 80 patients with liver cancer were selected as the research objects. It was hoped that the CNN-based MRI image segmentation algorithm could be applied to the guided analysis of MRI images of the targeted controlled release of doxorubicin nanopreparation to analyze the imaging analysis effect of this algorithm on the targeted treatment of liver cancer with doxorubicin nanopreparation. The results of this study showed that the upgraded three-dimensional (3D) CNN-based MRI image segmentation had a better effect compared with the traditional CNN-based MRI image segmentation, with significant improvement in indicators such as accuracy, precision, sensitivity, and specificity, and the differences were all statistically marked ( < 0.05). In the monitoring of the targeted drug therapy of doxorubicin nanopreparation for liver cancer patients, it was found that the MRI images of liver cancer patients processed by 3D CNN-based MRI image segmentation neural algorithm could be observed more intuitively and guided to accurately reach the target of liver cancer. The accuracy of targeted release determination of nanopreparation reached 80 ± 6.25%, which was higher markedly than that of the control group (66.6 ± 5.32%) ( < 0.05). In a word, the MRI image segmentation algorithm based on CNN had good application potential in guiding patients with liver cancer for targeted therapy with doxorubicin nanopreparation, which was worth promoting in the adjuvant treatment of targeted drugs for cancer.
研究卷积神经网络(CNN)为基础的磁共振成像(MRI)图像分割算法在多柔比星纳米材料 MRI 图像引导靶向药物治疗中的辅助作用,评估肝癌患者药物控释的价值。本研究选择 80 例肝癌患者作为研究对象,希望将基于 CNN 的 MRI 图像分割算法应用于多柔比星纳米制剂靶向控释的 MRI 图像引导分析,分析该算法对多柔比星纳米制剂靶向治疗肝癌的成像分析效果。研究结果表明,升级后的基于三维(3D)CNN 的 MRI 图像分割比传统的基于 CNN 的 MRI 图像分割效果更好,准确性、精密度、灵敏度和特异性等指标均有显著提高,差异均有统计学意义(<0.05)。在监测多柔比星纳米制剂对肝癌患者的靶向药物治疗中,发现经 3D CNN 基于 MRI 图像分割神经网络算法处理的肝癌患者 MRI 图像能够更直观地观察,并准确地引导到达肝癌的目标。纳米制剂靶向释放判断的准确性达到 80±6.25%,明显高于对照组(66.6±5.32%)(<0.05)。总之,基于 CNN 的 MRI 图像分割算法在指导肝癌患者多柔比星纳米制剂靶向治疗方面具有良好的应用潜力,在癌症靶向药物辅助治疗中值得推广。