Sharifi Shima, Talebi Sepide, Nattagh-Eshtivani Elyas, Amiri Yasaman, Askari Gholamreza
Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran 14155-6117, Iran.
Clin Nutr Res. 2021 Jul 30;10(3):257-267. doi: 10.7762/cnr.2021.10.3.257. eCollection 2021 Jul.
Our aim was to conduct a systematic review and meta-analysis on randomized controlled trials (RCTs) evaluating the effect of garlic on serum adiponectin levels. We searched Scopus, Web of Science, PubMed, and Cochrane Library to databases up to January 2021. RCTs investigating the effects of garlic on serum adiponectin levels in adult participants were included. The change in serum adiponectin levels was estimated using weighted mean differences (WMD) and standard deviations (SD). The random effects model was used to provide a summary of mean estimates and their SDs. Out of 386 records, 6 trials with 8 arms treatment which enrolled 266 subjects were included. Garlic supplementation resulted in a non-significant increase in adiponectin concentrations when compared to placebo, according to the pooled data (WMD, 0.27 Hedges' g; 95% confidence interval [CI], -0.07, 0.62; p = 0.124). Greater effects on adiponectin were observed in trials with supplementation dose less than 1.5 gram per day (WMD, 0.71 Hedges' g; 95% CI, -0.01, 1.43; p = 0.600) and in trials with female subset (WMD, 0.62 Hedges' g; 95% CI, -0.96, 2.21; p = 0.441). Garlic boosts adiponectin levels in general. However, due to different target population, various units for reporting adiponectin level and few eligible studies in final analysis, more research is needed to get a firm conclusion about the influence of garlic on adiponectin levels.
我们的目的是对评估大蒜对血清脂联素水平影响的随机对照试验（RCT）进行系统评价和荟萃分析。我们检索了Scopus、科学网、PubMed和Cochrane图书馆，直至2021年1月的数据库。纳入了研究大蒜对成年参与者血清脂联素水平影响的随机对照试验。使用加权平均差（WMD）和标准差（SD）估计血清脂联素水平的变化。采用随机效应模型对平均估计值及其标准差进行汇总。在386条记录中，纳入了6项试验，共8个治疗组，涉及266名受试者。根据汇总数据，与安慰剂相比，补充大蒜导致脂联素浓度无显著增加（WMD，0.27 Hedges'g；95%置信区间[CI]，-0.07，0.62；p = 0.124）。在每日补充剂量低于1.5克的试验（WMD，0.71 Hedges'g；95%CI，-0.01，1.43；p = 0.600）和女性亚组试验（WMD，0.62 Hedges'g；95%CI，-0.96，2.21；p = 0.441）中，观察到对脂联素有更大影响。总体而言，大蒜可提高脂联素水平。然而，由于目标人群不同、报告脂联素水平的单位各异以及最终分析中符合条件的研究较少，需要更多研究才能得出关于大蒜对脂联素水平影响的确切结论。
