红细胞在不含邻苯二甲酸二（2-乙基己基）酯的塑料容器中储存21天和35天的存活率。

Survival of red cells stored for 21 and 35 days in a non-di-(2-ethylhexyl)phthalate plastic container.

作者信息

Myhre B A, Johnson D, Marcus C S, Demaniew S, Carmen R, Nelson E

机构信息

Department of Pathology, Los Angeles County Harbor-UCLA Medical Center, Torrance.

出版信息

Vox Sang. 1987;53(4):199-202. doi: 10.1111/j.1423-0410.1987.tb05066.x.

DOI:10.1111/j.1423-0410.1987.tb05066.x

PMID:3439098

Abstract

Whole blood and red cells were stored using citrate-phosphate-dextrose (CPD) and citrate-phosphate-dextrose-adenine (CPDA-1) anticoagulants in polyvinylchloride bags made flexible with di-(2-ethylhexyl)phthalate (DEHP) or tri-(2-ethylhexyl)trimellitate (TOTM) plasticizers. After storage the posttransfusion viability of these cells was tested in autologous donors. Cells stored in TOTM-plasticized film had a survival rate less than 75% when stored for 35 days, while other systems had a survival greater than this. When compared with the red cells stored in CPD-DEHP-plasticized film, the viability of whole blood and red cells stored in CPDA-TOTM showed a statistically significant decrease (p = less than 0.01). Therefore, red cell storage in TOTM-plasticized PVC with current anticoagulant should be limited to 21 days.

摘要

全血和红细胞使用柠檬酸盐 - 磷酸盐 - 葡萄糖（CPD）和柠檬酸盐 - 磷酸盐 - 葡萄糖 - 腺嘌呤（CPDA - 1）抗凝剂，保存在用邻苯二甲酸二（2 - 乙基己基）酯（DEHP）或偏苯三酸三（2 - 乙基己基）酯（TOTM）增塑剂制成的柔性聚氯乙烯袋中。储存后，在自体供体中测试这些细胞的输血后活力。储存在TOTM增塑薄膜中的细胞在储存35天时存活率低于75%，而其他系统的存活率高于此。与储存在CPD - DEHP增塑薄膜中的红细胞相比，储存在CPDA - TOTM中的全血和红细胞活力有统计学显著下降（p = 小于0.01）。因此，使用当前抗凝剂在TOTM增塑的PVC中储存红细胞应限制在21天以内。