巴勒斯坦约旦河西岸北部镰状细胞病患者的血浆脂质和脂蛋白。
Plasma Lipids and Lipoproteins in Sickle Cell Disease Patients in the Northern West Bank, Palestine.
机构信息
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Arab American University, State of Palestine.
Department of Biology and Biochemistry, Faculty of Science, Birzeit University, Birzeit, State of Palestine.
出版信息
Biomed Res Int. 2021 Aug 4;2021:6640956. doi: 10.1155/2021/6640956. eCollection 2021.
BACKGROUND
Lipid metabolism may be altered in red cell genetic disorders. The erythrocyte and plasma lipids are defected which may increase the risk of cardiovascular disease. In the present study, we hypothesized a possible link between severity of anemia and altered lipid profile in SCD.
METHODS
A total of 151 SCD patients, including 62 patients with sickle cell anemia (SS), 54 patients with sickle -thalassemia (ST), and 35 individuals with sickle cell trait (AS), were studied. The control group consisted of 160 healthy individuals. Total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) were enzymatically measured.
RESULTS
Total cholesterol and LDL-C were significantly lower ( value < 0.001) in SS and ST patients compared to AS individuals and AA controls. However, LDL-C was significantly lower in AS individuals (both males and female) compared to AA controls ( value < 0.001). The HDL-C in SS and ST patients (both males and females) was significantly lower than that in AS individuals ( value < 0.001). In addition, the HDL-C was significantly higher in SS and ST males and AS (males and females) compared to AA controls ( value < 0.001). The HDL-C was also significantly higher in SS males ( value < 0.001) and females ( value < 0.05) compared to ST patients. The HDL-C was significantly higher in AS individuals ( value < 0.001) compared to AA controls. The triglycerides in SS males was significantly lower than that in ST patients ( value < 0.001), but there was no significant difference when compared to AS individuals and AA controls. In contrast, triglycerides in SS females were significantly lower than those in ST ( value < 0.05), AS ( value < 0.001), and AA controls ( value < 0.001). In males of ST patients, triglycerides were significantly higher than those observed in AS males and AA males ( value < 0.001). In contrast, females of ST patients have a significantly lower triglycerides compared to AS and AA females ( value < 0.001).
CONCLUSIONS
In SCD, the plasma is affected in some way, especially the plasma cholesterol that was investigated in this study. Further prospective studies should examine the contribution of an altered lipid profile to the severity and clinical complications in SCD patients.
背景
红细胞遗传疾病可能会改变脂质代谢。红细胞和血浆脂质出现缺陷，这可能会增加心血管疾病的风险。在本研究中，我们假设 SCD 患者的贫血严重程度与脂质谱改变之间可能存在关联。
方法
共纳入 151 名 SCD 患者，包括 62 名镰状细胞贫血（SS）患者、54 名镰状细胞 -地中海贫血（ST）患者和 35 名镰状细胞特征（AS）个体。对照组由 160 名健康个体组成。采用酶法测定总胆固醇（TC）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）。
结果
SS 和 ST 患者的总胆固醇和 LDL-C 明显低于 AS 个体和 AA 对照组（ 值<0.001）。然而，AS 个体（男性和女性）的 LDL-C 明显低于 AA 对照组（ 值<0.001）。SS 和 ST 患者（男性和女性）的 HDL-C 明显低于 AS 个体（ 值<0.001）。此外，SS 和 ST 男性和 AS（男性和女性）的 HDL-C 明显高于 AA 对照组（ 值<0.001）。SS 男性的 HDL-C 也明显高于 ST 患者（ 值<0.001）和女性（ 值<0.05）。AS 个体的 HDL-C 明显高于 AA 对照组（ 值<0.001）。SS 男性的甘油三酯明显低于 ST 患者（ 值<0.001），但与 AS 个体和 AA 对照组无显著差异。相反，SS 女性的甘油三酯明显低于 ST（ 值<0.05）、AS（ 值<0.001）和 AA 对照组（ 值<0.001）。ST 男性患者的甘油三酯明显高于 AS 男性和 AA 男性（ 值<0.001）。相反，ST 女性患者的甘油三酯明显低于 AS 和 AA 女性（ 值<0.001）。
结论
在 SCD 中，某种程度上会影响血浆，特别是本研究中研究的血浆胆固醇。进一步的前瞻性研究应检查脂质谱改变对 SCD 患者严重程度和临床并发症的贡献。
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