血管闭塞性危机中镰状细胞贫血患者的脂质代谢缺陷。
Defective lipid metabolism in sickle cell anaemia subjects in vaso-occlusive crisis.
作者信息
Akinlade Kehinde Sola, Adewale Christiana Odunayo, Rahamon Sheu Kadiri, Fasola Foluke Atinuke, Olaniyi John Ayodele, Atere Adedeji David
机构信息
Department of Chemical Pathology, University of Ibadan/University College Hospital, Ibadan, Nigeria.
Department of Haematology, University of Ibadan/University College Hospital, Ibadan, Nigeria.
出版信息
Niger Med J. 2014 Sep;55(5):428-31. doi: 10.4103/0300-1652.140388.
BACKGROUND
Abnormal lipid homeostasis has been reported in sickle cell anaemia (SCA) as well as in other haematological disorders. However, there is little information on the lipid profile of SCA subjects in vaso-occlusive crisis (VOC). This study determined the lipid profile of adult SCA subjects in VOC and in steady state (SSCA).
MATERIALS AND METHODS
Fifty-eight (58) adults with HbSS (30 in steady state and 28 in vaso-occlusive crisis) and 24 age-matched healthy individuals with HbAA genotype were recruited into this study. Standard methods were used for the determination of blood pressure (BP), packed cell volume (PCV), total white blood cell count (WBC) and haemoglobin phenotype. After an overnight fast, 5 ml of venous blood was obtained from each SSCA and the controls while samples were collected upon admission in the VOC group. Plasma lipid profile was determined using enzymatic method. Differences between two groups were determined using independent Student's t-test or Man-Whitney U as appropriate. P-values less than 0.05 were considered significant.
RESULTS
Plasma total cholesterol (TC) and high density lipoprotein (HDL) were significantly lower while the ratio of triglyceride (TG) to HDL (TG/HDL) was significantly higher in SSCA compared with the controls. Low density lipoprotein (LDL) and TC were significantly lower in SCA subjects in VOC compared with controls. However, TC, TG, LDL and TG/HDL were significantly lower while HDL was significantly higher in VOC compared with SSCA.
CONCLUSION
Sickle cell anaemia subjects have defective fasting lipid metabolism which becomes pronounced with VOC.
背景
已有报道称镰状细胞贫血（SCA）以及其他血液系统疾病存在脂质稳态异常。然而，关于血管闭塞性危机（VOC）中SCA患者的血脂情况，相关信息较少。本研究测定了处于VOC期和稳定期（SSCA）的成年SCA患者的血脂情况。
材料与方法
本研究招募了58例HbSS成年患者（30例处于稳定期，28例处于血管闭塞性危机期）以及24例年龄匹配、基因型为HbAA的健康个体。采用标准方法测定血压（BP）、红细胞压积（PCV）、白细胞总数（WBC）和血红蛋白表型。SSCA组患者和对照组患者均在禁食过夜后采集5ml静脉血，VOC组患者在入院时采集样本。采用酶法测定血浆脂质谱。根据情况使用独立样本t检验或曼-惠特尼U检验来确定两组之间的差异。P值小于0.05被认为具有统计学意义。
结果
与对照组相比，SSCA组患者的血浆总胆固醇（TC）和高密度脂蛋白（HDL）显著降低，而甘油三酯（TG）与HDL的比值（TG/HDL）显著升高。与对照组相比，处于VOC期的SCA患者的低密度脂蛋白（LDL）和TC显著降低。然而，与SSCA组相比，VOC组患者的TC、TG、LDL和TG/HDL显著降低，而HDL显著升高。
结论
镰状细胞贫血患者存在空腹脂质代谢缺陷，在血管闭塞性危机期更为明显。
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