Erasmus R T, Olukoga A O, Ojuawo O
Department of Chemical Pathology and Immunology, University of Ilorin, Nigeria.
Ann Trop Paediatr. 1990;10(4):421-3. doi: 10.1080/02724936.1990.11747468.
Plasma lipids and lipoproteins were estimated in 67 Nigerian children (mean age 10.19 years) with sickle cell anaemia (HbS) and 67 age- and sex-matched non-anaemic controls with normal haemoglobin (HbA). Plasma cholesterol and HDL-cholesterol levels were significantly lower while the plasma triglyceride level was significantly higher in the subjects with sickle cell anaemia. LDL-cholesterol levels were higher in sickle cell anaemia patients, but were not of statistical significance. These results do not support suggestions that sickle cell anaemia patients are at low risk of developing coronary artery disease.
对67名患有镰状细胞贫血（HbS）的尼日利亚儿童（平均年龄10.19岁）以及67名年龄和性别匹配、血红蛋白正常（HbA）的非贫血对照者进行了血浆脂质和脂蛋白评估。镰状细胞贫血患者的血浆胆固醇和高密度脂蛋白胆固醇水平显著较低，而血浆甘油三酯水平显著较高。镰状细胞贫血患者的低密度脂蛋白胆固醇水平较高，但无统计学意义。这些结果不支持镰状细胞贫血患者患冠状动脉疾病风险较低的观点。
