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To study neuropeptide Y (NPY) effect on melatonin production, rat pineal explants were incubated for 6 hr with 10-1,000 nM NPY in the presence or absence of 10 microM norepinephrine (NE). Melatonin content in the pineal gland and media was measured by radioimmunoassay (RIA). 2. NPY (10-1,000 nM) increased melatonin production and, at 10 or 100 nM concentrations (but not 1,000 nM), enhanced NE stimulation of melatonin production. 3. NPY (1,000 nM) impaired 3H-labeled transmitter release induced by a K+ depolarizing stimulus in rat pineals incubated with 3H-NE. 4. These results suggest that NPY affects both pre- and postsynaptic pineal mechanisms.

为研究神经肽Y（NPY）对褪黑素分泌的影响，将大鼠松果体组织块在存在或不存在10微摩尔去甲肾上腺素（NE）的情况下，用10 - 1000纳摩尔的NPY孵育6小时。通过放射免疫分析（RIA）测定松果体和培养基中的褪黑素含量。2. NPY（10 - 1000纳摩尔）增加了褪黑素的分泌，并且在10或100纳摩尔浓度时（但不是1000纳摩尔），增强了NE对褪黑素分泌的刺激作用。3. 在与3H - NE一起孵育的大鼠松果体中，NPY（1000纳摩尔）损害了由K + 去极化刺激诱导的3H标记递质释放。4. 这些结果表明，NPY影响突触前和突触后松果体机制。

To study neuropeptide Y (NPY) effect on melatonin production, rat pineal explants were incubated for 6 hr with 10-1,000 nM NPY in the presence or absence of 10 microM norepinephrine (NE). Melatonin content in the pineal gland and media was measured by radioimmunoassay (RIA). 2. NPY (10-1,000 nM) increased melatonin production and, at 10 or 100 nM concentrations (but not 1,000 nM), enhanced NE stimulation of melatonin production. 3. NPY (1,000 nM) impaired 3H-labeled transmitter release induced by a K+ depolarizing stimulus in rat pineals incubated with 3H-NE. 4. These results suggest that NPY affects both pre- and postsynaptic pineal mechanisms.

为研究神经肽Y（NPY）对褪黑素分泌的影响，将大鼠松果体组织块在存在或不存在10微摩尔去甲肾上腺素（NE）的情况下，用10 - 1000纳摩尔的NPY孵育6小时。通过放射免疫分析（RIA）测定松果体和培养基中的褪黑素含量。2. NPY（10 - 1000纳摩尔）增加了褪黑素的分泌，并且在10或100纳摩尔浓度时（但不是1000纳摩尔），增强了NE对褪黑素分泌的刺激作用。3. 在与3H - NE一起孵育的大鼠松果体中，NPY（1000纳摩尔）损害了由K + 去极化刺激诱导的3H标记递质释放。4. 这些结果表明，NPY影响突触前和突触后松果体机制。

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