神经肽Y对大鼠松果体褪黑素和去甲肾上腺素释放的体外作用。
In vitro effect of neuropeptide Y on melatonin and norepinephrine release in rat pineal gland.
作者信息
Vacas M I, Sarmiento M I, Pereyra E N, Etchegoyen G S, Cardinali D P
机构信息
Departamento de Fisiología, Facultad de Medicina, UBA, Buenos Aires, Argentina.
出版信息
Cell Mol Neurobiol. 1987 Sep;7(3):309-15. doi: 10.1007/BF00711307.
Abstract
- To study neuropeptide Y (NPY) effect on melatonin production, rat pineal explants were incubated for 6 hr with 10-1,000 nM NPY in the presence or absence of 10 microM norepinephrine (NE). Melatonin content in the pineal gland and media was measured by radioimmunoassay (RIA). 2. NPY (10-1,000 nM) increased melatonin production and, at 10 or 100 nM concentrations (but not 1,000 nM), enhanced NE stimulation of melatonin production. 3. NPY (1,000 nM) impaired 3H-labeled transmitter release induced by a K+ depolarizing stimulus in rat pineals incubated with 3H-NE. 4. These results suggest that NPY affects both pre- and postsynaptic pineal mechanisms.
摘要
- 为研究神经肽Y（NPY）对褪黑素分泌的影响，将大鼠松果体组织块在存在或不存在10微摩尔去甲肾上腺素（NE）的情况下，用10 - 1000纳摩尔的NPY孵育6小时。通过放射免疫分析（RIA）测定松果体和培养基中的褪黑素含量。2. NPY（10 - 1000纳摩尔）增加了褪黑素的分泌，并且在10或100纳摩尔浓度时（但不是1000纳摩尔），增强了NE对褪黑素分泌的刺激作用。3. 在与3H - NE一起孵育的大鼠松果体中，NPY（1000纳摩尔）损害了由K + 去极化刺激诱导的3H标记递质释放。4. 这些结果表明，NPY影响突触前和突触后松果体机制。
相似文献
1
In vitro effect of neuropeptide Y on melatonin and norepinephrine release in rat pineal gland.神经肽Y对大鼠松果体褪黑素和去甲肾上腺素释放的体外作用。
Cell Mol Neurobiol. 1987 Sep;7(3):309-15. doi: 10.1007/BF00711307.
2
Role of prostaglandins in rat pineal neuroeffector junction. Changes in melatonin and norepinephrine release in vitro.前列腺素在大鼠松果体神经效应器连接中的作用。褪黑素和去甲肾上腺素体外释放的变化。
Endocrinology. 1982 Aug;111(2):530-4. doi: 10.1210/endo-111-2-530.
3
Neuropeptide Y: an endogenous inhibitor of norepinephrine-stimulated melatonin secretion in the rat pineal gland.
J Neurochem. 1991 Sep;57(3):943-7. doi: 10.1111/j.1471-4159.1991.tb08241.x.
4
Effect of adenosine on melatonin and norepinephrine release in rat pineal explants.腺苷对大鼠松果体体外培养物中褪黑素和去甲肾上腺素释放的影响。
Acta Physiol Pharmacol Latinoam. 1989;39(2):189-95.
5
Release and effect of gamma-aminobutyric acid (GABA) on rat pineal melatonin production in vitro.γ-氨基丁酸（GABA）对大鼠松果体褪黑素体外分泌的释放及影响
Cell Mol Neurobiol. 1989 Jun;9(2):207-19. doi: 10.1007/BF00713029.
6
Involvement of 5-lipoxygenase pathway in norepinephrine stimulation of rat pineal melatonin synthesis.5-脂氧合酶途径参与去甲肾上腺素对大鼠松果体褪黑素合成的刺激作用。
Neuroendocrinology. 1987 Nov;46(5):412-6. doi: 10.1159/000124854.
7
Neuropeptide Y as a presynaptic modulator of norepinephrine release from the sympathetic nerve fibers in the pig pineal gland.神经肽Y作为猪松果体中去甲肾上腺素从交感神经纤维释放的突触前调节剂。
Pol J Vet Sci. 2015;18(1):53-61. doi: 10.1515/pjvs-2015-0007.
8
Neuropeptide Y effects on pineal melatonin synthesis in the rat.
Neurosci Lett. 1987 Feb 24;74(2):158-62. doi: 10.1016/0304-3940(87)90142-x.
9
Presynaptic effects of melatonin on norepinephrine release and uptake in rat pineal gland.褪黑素对大鼠松果体去甲肾上腺素释放和摄取的突触前效应。
J Pineal Res. 1991;10(4):165-73. doi: 10.1111/j.1600-079x.1991.tb00811.x.
10
Rhythmic melatonin response of the Syrian hamster pineal gland to norepinephrine in vitro and in vivo.叙利亚仓鼠松果体在体外和体内对去甲肾上腺素的节律性褪黑素反应。
J Pineal Res. 1986;3(3):235-49. doi: 10.1111/j.1600-079x.1986.tb00746.x.
引用本文的文献
1
Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling.神经肽 Y 通过调节去甲肾上腺素能信号调节睡眠。
Curr Biol. 2017 Dec 18;27(24):3796-3811.e5. doi: 10.1016/j.cub.2017.11.018. Epub 2017 Dec 7.
2
Neurotranscriptomics: The Effects of Neonatal Stimulus Deprivation on the Rat Pineal Transcriptome.神经转录组学：新生儿刺激剥夺对大鼠松果体转录组的影响。
PLoS One. 2015 Sep 14;10(9):e0137548. doi: 10.1371/journal.pone.0137548. eCollection 2015.
3
Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure.严重充血性心力衰竭患者尿中6-硫酸氧褪黑素水平较低。
Endocrine. 2003 Dec;22(3):245-8. doi: 10.1385/ENDO:22:3:245.
4
Adrenergic and peptidergic control of the regulation of cAMP efflux and melatonin secretion from perifused rat pineal gland.肾上腺素能和肽能对灌流大鼠松果体中环磷酸腺苷流出及褪黑素分泌调节的控制
Endocrine. 1998 Aug;9(1):89-96. doi: 10.1385/ENDO:9:1:89.
5
Lack of effect of oxytocin on the numbers of "synaptic" ribbons, cyclic guanosine monophosphate and serotonin N-acetyltransferase activity in organ-cultured pineals of three strains of rats.催产素对三种品系大鼠器官培养松果体中“突触”带数量、环磷酸鸟苷及血清素N - 乙酰转移酶活性无影响。
Cell Tissue Res. 1993 Nov;274(2):337-42. doi: 10.1007/BF00318752.
6
Cellular and molecular mechanisms controlling melatonin release by mammalian pineal glands.控制哺乳动物松果体褪黑素释放的细胞和分子机制。
Cell Mol Neurobiol. 1987 Dec;7(4):323-37. doi: 10.1007/BF00733786.
7
Innervation of the mink pineal gland with neuropeptide Y (NPY)-containing nerve fibers. An experimental immunohistochemical study.水貂松果体的含神经肽Y（NPY）神经纤维支配。一项实验性免疫组织化学研究。
Cell Tissue Res. 1990 Sep;261(3):477-83. doi: 10.1007/BF00313526.
8
Tyrosine hydroxylase- and neuropeptide Y-immunoreactive nerve fibers in the pineal complex of untreated rats and rats following removal of the superior cervical ganglia.未处理大鼠及切除颈上神经节后大鼠松果体复合体中酪氨酸羟化酶和神经肽Y免疫反应性神经纤维。
Cell Tissue Res. 1991 Jul;265(1):63-71. doi: 10.1007/BF00318140.
9
Tyrosine hydroxylase and neuropeptide-Y immunoreactivity in pineal glands developing in situ and in pineal grafts.原位发育的松果体及松果体移植中酪氨酸羟化酶和神经肽Y免疫反应性
Cell Tissue Res. 1991 Jun;264(3):515-27. doi: 10.1007/BF00319041.
本文引用的文献
1
Role of prostaglandins in rat pineal neuroeffector junction. Changes in melatonin and norepinephrine release in vitro.前列腺素在大鼠松果体神经效应器连接中的作用。褪黑素和去甲肾上腺素体外释放的变化。
Endocrinology. 1982 Aug;111(2):530-4. doi: 10.1210/endo-111-2-530.
2
Vasoactive intestinal peptide stimulation of pineal serotonin-N-acetyltransferase activity: general characteristics.
J Neurochem. 1983 Jul;41(1):146-53. doi: 10.1111/j.1471-4159.1983.tb11826.x.
3
Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function.外周去甲肾上腺素能神经元中的神经肽Y（NPY）样免疫反应性及NPY对交感神经功能的影响。
Acta Physiol Scand. 1982 Dec;116(4):477-80. doi: 10.1111/j.1748-1716.1982.tb07171.x.
4
Neuropeptide Y (NPY) depresses the secretion of 3H-noradrenaline and the contractile response evoked by field stimulation, in rat vas deferens.神经肽Y（NPY）可抑制大鼠输精管中3H-去甲肾上腺素的分泌以及场刺激所诱发的收缩反应。
Acta Physiol Scand. 1984 Mar;120(3):477-9. doi: 10.1111/j.1748-1716.1984.tb07410.x.
5
Postsynaptic alpha-adrenergic receptors potentiate the beta-adrenergic stimulation of pineal serotonin N-acetyltransferase.突触后α-肾上腺素能受体增强松果体5-羟色胺N-乙酰转移酶的β-肾上腺素能刺激作用。
Proc Natl Acad Sci U S A. 1983 Jan;80(2):599-603. doi: 10.1073/pnas.80.2.599.
6
The anatomy of neuropeptide-Y-containing neurons in rat brain.大鼠脑中含神经肽Y的神经元的解剖结构。
Neuroscience. 1985 Aug;15(4):1159-81. doi: 10.1016/0306-4522(85)90260-x.
7
Neuropeptide Y-like immunoreactivity in perivascular nerve fibres of the guinea-pig.豚鼠血管周围神经纤维中的神经肽Y样免疫反应性
Regul Pept. 1985 Mar;10(2-3):243-57. doi: 10.1016/0167-0115(85)90019-9.
8
Neuropeptide Y innervation of the rodent pineal gland and cerebral blood vessels.啮齿动物松果体和脑血管的神经肽Y神经支配。
Neurosci Lett. 1985 Jun 4;57(1):65-71. doi: 10.1016/0304-3940(85)90041-2.
9
Neuropeptide Y effects on pineal melatonin synthesis in the rat.
Neurosci Lett. 1987 Feb 24;74(2):158-62. doi: 10.1016/0304-3940(87)90142-x.
10
Neuropeptide Y (NPY)-like immunoreactivity in peripheral and central nerve fibres of the golden hamster (Mesocricetus auratus) with special respect to pineal gland innervation.
Histochemistry. 1986;85(4):321-5. doi: 10.1007/BF00493484.
Zotero 插件