School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.
Department of Orthopaedic Surgery & Musculoskeletal Medicine, University of Otago Christchurch, Christchurch, New Zealand.
PLoS One. 2021 Aug 17;16(8):e0256072. doi: 10.1371/journal.pone.0256072. eCollection 2021.
Knee and hip arthroplasty are common surgeries within an aging population. Some data has suggested that knee arthroplasty is more traumatic to the body than hip arthroplasty due to the increased complexity and load bearing nature of the joint. Here, we compare the stress of the two surgeries by measuring urinary neopterin and total neopterin as biomarkers of oxidative stress and inflammation. Urinary neopterin and total neopterin (neopterin + 7,8-dihydroneopterin) levels were analysed in 28 knee and 22 hip arthroplasty patients pre- and post-operatively to determine oxidative stress and inflammation levels. Total neopterin was 31.1% higher with knee arthroplasty (p<0.05). Urinary neopterin was 32.8% higher in the knee arthroplasty group versus hips. The increase in neopterin and total neopterin following a post-surgical decrease in levels was significant in both groups. Levels of neopterin and total neopterin were varied between patients, but all increased following surgery and subsided by day 28. The increased levels of urinary neopterin and total neopterin from knee arthroplasty indicate that knee osteoarthritis and arthroplasty is a more significant trauma to the body than hip osteoarthritis and arthroplasty surgery. This is also shown by faster inflammatory resolution following hip arthroplasty.
膝关节和髋关节置换术是老龄化人群中常见的手术。一些数据表明，膝关节置换术比髋关节置换术对身体的创伤更大，因为膝关节的复杂性和承重性质增加。在这里，我们通过测量尿中新蝶呤和总新蝶呤作为氧化应激和炎症的生物标志物来比较这两种手术的应激。在膝关节和髋关节置换术前和术后，分析了 28 例膝关节和 22 例髋关节置换术患者的尿中新蝶呤和总新蝶呤（新蝶呤+7,8-二氢新蝶呤）水平，以确定氧化应激和炎症水平。膝关节置换术后总新蝶呤升高 31.1%（p<0.05）。与髋关节相比，膝关节置换组的尿中新蝶呤升高 32.8%。两组术后新蝶呤和总新蝶呤水平下降后均有显著升高。新蝶呤和总新蝶呤的水平在患者之间有所不同，但所有水平均在手术后升高，并在第 28 天下降。膝关节置换术后尿中新蝶呤和总新蝶呤水平升高表明，与髋关节骨关节炎和关节置换术相比，膝关节骨关节炎和关节置换术对身体的创伤更大。髋关节置换术后炎症更快消退也表明了这一点。
