Shaw R W
J Int Med Res. 1978;6(2):147-51. doi: 10.1177/030006057800600215.
A randomized controlled trial was performed to study the efficacy of Syn-Ergel with an active placebo in the treatment of heartburn of pregnancy in ninety-two patients completing 7 days of therapy. Syn-Ergel was significantly better (p less than 0.001) in all groups of pre-treatment pain severity in relieving the symptoms, and had a longer duration of action, than the active placebo. Complete relief of pain was achieved in 79.5% of Syn-Ergel treatments with a further 10% of treatments resulting in marked easing of discomfort at 1 hour following administration. The corresponding figures for the 'active placebo' were 56% and 20%. The combination of an antacid and a protective mucosal coating agent would appear to be a useful approach in the treatment of heartburn of pregnacy.
一项随机对照试验对92例完成7天治疗的妊娠烧心患者进行了研究，比较了Syn-Ergel与活性安慰剂治疗妊娠烧心的疗效。在缓解症状方面，Syn-Ergel在所有治疗前疼痛严重程度组中均显著优于活性安慰剂（p<0.001），且作用持续时间更长。79.5%接受Syn-Ergel治疗的患者疼痛完全缓解，另有10%的治疗在给药后1小时明显减轻不适。“活性安慰剂”组的相应数字分别为56%和20%。抗酸剂和保护性粘膜涂层剂联合使用似乎是治疗妊娠烧心的一种有效方法。
