Akbari Ahmad, Haghpanah Sezaneh, Barzegar Hamide, Shahsavani Amin, Afrasiabi Abdolreza, Parand Shirin, Karimi Mehran
Thrombosis and Hemostasis Research Center, Dastghieb Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Heliyon. 2021 Aug 8;7(8):e07734. doi: 10.1016/j.heliyon.2021.e07734. eCollection 2021 Aug.
Thromboembolic events mainly occur in older age is related with high morbidity and mortality, and considerable health-care costs particularly in developing countries. Both arterial and venous thromboembolism has known risk factors such as hyperlipidemia, obesity, diabetes, cancer, major surgery, central catheter. We aimed to evaluate the occurrence of thrombotic events and related risk factors in a group of Iranian patients.
In this cross-sectional study, all patients (n = 99) who were complicated by thrombotic events referred to the Hematology Research Center of Shiraz University of Medical Sciences were investigated from 2015 to 2017, in Shiraz, Southern Iran. Data were collected from their medical records by a designed data gathering form.
The median age of the occurrence of thrombosis was 51 (IQR: 31) years. From all thrombotic events 52.5% occurred in females. Venous thrombosis was more prevalent than arterial (61.6% vs. 38.4%). Hypertension, diabetes mellitus and ischemic heart disease were the most associated disease with thrombosis. Most of the patients (79.8%) had no episodes of relapse and the occurrence of relapse had no significant relationship with thrombophilia and underlying disease. Acceptable response rate for warfarin therapy was achieved in 46.5% with 5 mg and 43.4% with 5-7.5 mg.
Knowing the frequency and risk factors for thrombotic events lead to timely diagnosis and management of thrombosis. Atrial fibrillation and valvular rheumatic heart disease are the most common risk factors of thrombosis in our study showing prophylaxis is necessary in high-risk patients.
血栓栓塞事件主要发生于老年人，与高发病率和死亡率相关，且会产生可观的医疗费用，在发展中国家尤为如此。动脉和静脉血栓栓塞都有已知的危险因素，如高脂血症、肥胖、糖尿病、癌症、大手术、中心静脉导管。我们旨在评估一组伊朗患者血栓形成事件的发生率及相关危险因素。
在这项横断面研究中，2015年至2017年期间，对所有转诊至设拉子医科大学血液学研究中心且并发血栓形成事件的患者（n = 99）进行了调查，研究地点位于伊朗南部的设拉子。通过设计好的数据收集表从他们的病历中收集数据。
血栓形成的中位年龄为51岁（四分位间距：31岁）。在所有血栓形成事件中，52.5%发生在女性。静脉血栓形成比动脉血栓形成更常见（61.6%对38.4%）。高血压、糖尿病和缺血性心脏病是与血栓形成最相关的疾病。大多数患者（79.8%）没有复发情况，复发的发生与血栓形成倾向和基础疾病无显著关系。华法林治疗的可接受反应率在5 mg时为46.5%，在5 - 7.5 mg时为43.4%。
了解血栓形成事件的发生率和危险因素有助于及时诊断和处理血栓形成。在我们的研究中，心房颤动和风湿性瓣膜性心脏病是血栓形成最常见的危险因素，表明对高危患者进行预防是必要的。
