与杀手的伙伴关系：代谢信号传导促进炎性细胞死亡。
Partners with a killer: Metabolic signaling promotes inflammatory cell death.
作者信息
Liu Zhonghua, Xiao Tsan Sam
机构信息
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
出版信息
Cell. 2021 Aug 19;184(17):4374-4376. doi: 10.1016/j.cell.2021.07.036.
Abstract
In this issue of Cell, Evavold et al. (2021) report that mTOR Complex 1 (mTORC1), a metabolic signaling complex, controls reactive oxygen species (ROS) production in mitochondria, which in turn promotes inflammatory cell death mediated by gasdermin D (GSDMD). This provides a new mechanistic connection between metabolic signaling and inflammatory cell death.
摘要
在本期《细胞》杂志中，伊瓦尔德等人（2021年）报道，作为一种代谢信号复合物的mTOR复合物1（mTORC1）控制线粒体中活性氧（ROS）的产生，进而促进由gasdermin D（GSDMD）介导的炎性细胞死亡。这为代谢信号与炎性细胞死亡之间提供了一种新的机制联系。
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本文引用的文献
1
The Lysosomal Rag-Ragulator Complex Licenses RIPK1 and Caspase-8-mediated Pyroptosis by .溶酶体 Rag-Ragulator 复合物通过. 许可 RIPK1 和 Caspase-8 介导热激原性细胞死亡。
Science. 2021 Jun 25;372(6549). doi: 10.1126/science.abg0269.
2
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.Ragulator-Rag-mTORC1 通路对 GSDMD 寡聚化和细胞焦亡的调控作用。
Cell. 2021 Aug 19;184(17):4495-4511.e19. doi: 10.1016/j.cell.2021.06.028. Epub 2021 Jul 21.
3
Gasdermin D pore structure reveals preferential release of mature interleukin-1.Gasdermin D 孔结构揭示了成熟白细胞介素-1 的优先释放。
Nature. 2021 May;593(7860):607-611. doi: 10.1038/s41586-021-03478-3. Epub 2021 Apr 21.
4
Channelling inflammation: gasdermins in physiology and disease.炎症通道：Gasdermin 在生理和疾病中的作用。
Nat Rev Drug Discov. 2021 May;20(5):384-405. doi: 10.1038/s41573-021-00154-z. Epub 2021 Mar 10.
5
mTOR at the nexus of nutrition, growth, ageing and disease.mTOR 在营养、生长、衰老和疾病的交汇点。
Nat Rev Mol Cell Biol. 2020 Apr;21(4):183-203. doi: 10.1038/s41580-019-0199-y. Epub 2020 Jan 14.
6
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.Gasdermin D（GSDMD）膜孔形成构成了细胞焦亡性细胞死亡的机制。
EMBO J. 2016 Aug 15;35(16):1766-78. doi: 10.15252/embj.201694696. Epub 2016 Jul 14.
7
GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes.细胞焦亡过程中由半胱天冬酶-11诱导产生的Gasdermin D p30在细胞膜上形成孔道。
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7858-63. doi: 10.1073/pnas.1607769113. Epub 2016 Jun 23.
8
Pore-forming activity and structural autoinhibition of the gasdermin family.气 分 子 家 族 的 孔 形 成 活 性 和 结 构 自 抑 制 。
Nature. 2016 Jul 7;535(7610):111-6. doi: 10.1038/nature18590. Epub 2016 Jun 8.
9
A role for mitochondria in NLRP3 inflammasome activation.线粒体在 NLRP3 炎性小体激活中的作用。
Nature. 2011 Jan 13;469(7329):221-5. doi: 10.1038/nature09663. Epub 2010 Dec 1.
10
Pro-inflammatory programmed cell death.促炎性程序性细胞死亡
Trends Microbiol. 2001 Mar;9(3):113-4. doi: 10.1016/s0966-842x(00)01936-3.
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