Liu Zhonghua, Xiao Tsan Sam
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Cell. 2021 Aug 19;184(17):4374-4376. doi: 10.1016/j.cell.2021.07.036.
In this issue of Cell, Evavold et al. (2021) report that mTOR Complex 1 (mTORC1), a metabolic signaling complex, controls reactive oxygen species (ROS) production in mitochondria, which in turn promotes inflammatory cell death mediated by gasdermin D (GSDMD). This provides a new mechanistic connection between metabolic signaling and inflammatory cell death.
在本期《细胞》杂志中，伊瓦尔德等人（2021年）报道，作为一种代谢信号复合物的mTOR复合物1（mTORC1）控制线粒体中活性氧（ROS）的产生，进而促进由gasdermin D（GSDMD）介导的炎性细胞死亡。这为代谢信号与炎性细胞死亡之间提供了一种新的机制联系。
