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荧光纳米电缆作为一种生物医学工具：一种天然产物形成的细胞内自组装将线粒体连接并同步化。

Fluorescent Nanocable as a Biomedical Tool: Intracellular Self-Assembly Formed by a Natural Product Interconnects and Synchronizes Mitochondria.

机构信息

School of Life Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China.

Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong 999077, China.

出版信息

ACS Nano. 2024 Aug 13;18(32):21447-21458. doi: 10.1021/acsnano.4c06186. Epub 2024 Jul 30.

DOI:10.1021/acsnano.4c06186
PMID:39080909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11328177/
Abstract

Self-assembly processes commonly occur in various biological contexts to form functional biological structures. However, the self-assembly of nanofibers within cells by heterologous molecules showing a biological function is rare. In this work, we reported the intracellular formation of fluorescent nanofibers by a natural small molecule, lycobetaine (LBT), which facilitated the direct physical connection between mitochondria and synchronized their membrane potential oscillations. The luminescent properties of LBT enabled the real-time observation of nanofiber formation, while the semiconductive nature of the LBT nanofiber facilitated electrical signal transduction among the connected mitochondria. This study introduces an approach to modulate mitochondrial connectivity within cells using "nano-cables" which facilitate studies on synchronized mitochondrial operations and the underlying mechanisms of drug action.

摘要

自组装过程在各种生物环境中普遍存在，用于形成功能性生物结构。然而，具有生物功能的异源分子在细胞内自组装成纳米纤维的情况很少见。在这项工作中，我们报道了天然小分子甜菜碱（LBT）在细胞内形成荧光纳米纤维，这促进了线粒体之间的直接物理连接，并使其膜电位振荡同步。LBT 的发光性质使得纳米纤维形成的实时观察成为可能，而 LBT 纳米纤维的半导体性质则促进了连接的线粒体之间的电信号转导。这项研究介绍了一种使用“纳米电缆”调节细胞内线粒体连接的方法，这有助于研究同步线粒体操作和药物作用的潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/78ffaf0fd901/nn4c06186_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/607b63f76f56/nn4c06186_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/8993e8a412fe/nn4c06186_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/9a0c66556bcc/nn4c06186_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/c644e78ee444/nn4c06186_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/7663f9eb355d/nn4c06186_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/12c46a9db881/nn4c06186_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/78ffaf0fd901/nn4c06186_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/607b63f76f56/nn4c06186_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/8993e8a412fe/nn4c06186_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/9a0c66556bcc/nn4c06186_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/c644e78ee444/nn4c06186_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/7663f9eb355d/nn4c06186_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/12c46a9db881/nn4c06186_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f00e/11328177/78ffaf0fd901/nn4c06186_0007.jpg

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LonP1 Links Mitochondria-ER Interaction to Regulate Heart Function.LonP1 将线粒体与内质网的相互作用联系起来以调节心脏功能。
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