大鼠IgE抗体在小鼠体内诱导被动皮肤过敏反应（PCA）及反向PCA的产生。
Production of passive cutaneous anaphylaxis (PCA) and reversed PCA by rat IgE antibody in the mouse.
作者信息
Harada M, Nagata M, Takeuchi M
机构信息
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
出版信息
Experientia. 1988 May 15;44(5):459-62. doi: 10.1007/BF01940548.
Although IgE antibody is generally characterized as a homocytotropic antibody, it has been well known for some time that mouse IgE antibody causes potent sensitization of rat skin for PCA. The present study clearly shows the reciprocal cross-sensitization of mouse skin with rat IgE molecules. PCA and RPCA were produced by rat IgE antibody in an inbred mouse strain. DS/Shi, though not in C3H/HeShi, C57BL/6JShi and BALB/cCrj strains. Sensitization of DS/Shi mouse skin for PCA with rat IgE antibody was comparable in sensitivity with that of rat skin, but lasted only for a short term in comparison with the long persistence in rat skin.
虽然IgE抗体通常被认为是亲同种细胞抗体，但一段时间以来人们就已经知道，小鼠IgE抗体可使大鼠皮肤对被动皮肤过敏反应（PCA）产生强烈致敏作用。本研究清楚地表明了小鼠皮肤与大鼠IgE分子之间的相互交叉致敏作用。在近交系小鼠品系DS/Shi中，大鼠IgE抗体可产生PCA和反向被动皮肤过敏反应（RPCA），但在C3H/HeShi、C57BL/6JShi和BALB/cCrj品系中则不能。用大鼠IgE抗体使DS/Shi小鼠皮肤对PCA致敏，其敏感性与大鼠皮肤相当，但与大鼠皮肤中致敏作用的长期持续相比，DS/Shi小鼠皮肤中的致敏作用仅持续较短时间。
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