Wiendl Heinz, Gold Ralf, Berger Thomas, Derfuss Tobias, Linker Ralf, Mäurer Mathias, Aktas Orhan, Baum Karl, Berghoff Martin, Bittner Stefan, Chan Andrew, Czaplinski Adam, Deisenhammer Florian, Di Pauli Franziska, Du Pasquier Renaud, Enzinger Christian, Fertl Elisabeth, Gass Achim, Gehring Klaus, Gobbi Claudio, Goebels Norbert, Guger Michael, Haghikia Aiden, Hartung Hans-Peter, Heidenreich Fedor, Hoffmann Olaf, Kallmann Boris, Kleinschnitz Christoph, Klotz Luisa, Leussink Verena I, Leutmezer Fritz, Limmroth Volker, Lünemann Jan D, Lutterotti Andreas, Meuth Sven G, Meyding-Lamadé Uta, Platten Michael, Rieckmann Peter, Schmidt Stephan, Tumani Hayrettin, Weber Frank, Weber Martin S, Zettl Uwe K, Ziemssen Tjalf, Zipp Frauke
Klinik für Neurologie mit Institut für Translationale Neurologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Münster.
Neurologie, St. Josef-Hospital, Klinikum der Ruhr-Universität Bochum, Gudrunstraße 56, 44791 Bochum, Germany.
Ther Adv Neurol Disord. 2021 Aug 18;14:17562864211039648. doi: 10.1177/17562864211039648. eCollection 2021.
Multiple sclerosis is a complex, autoimmune-mediated disease of the central nervous system characterized by inflammatory demyelination and axonal/neuronal damage. The approval of various disease-modifying therapies and our increased understanding of disease mechanisms and evolution in recent years have significantly changed the prognosis and course of the disease. This update of the Multiple Sclerosis Therapy Consensus Group treatment recommendation focuses on the most important recommendations for disease-modifying therapies of multiple sclerosis in 2021. Our recommendations are based on current scientific evidence and apply to those medications approved in wide parts of Europe, particularly German-speaking countries (Germany, Austria, and Switzerland).
多发性硬化症是一种复杂的、自身免疫介导的中枢神经系统疾病，其特征为炎症性脱髓鞘以及轴突/神经元损伤。近年来，多种疾病修正疗法的获批以及我们对疾病机制和演变的深入了解，显著改变了该疾病的预后和病程。多发性硬化症治疗共识小组治疗建议的此次更新聚焦于2021年多发性硬化症疾病修正疗法的最重要建议。我们的建议基于当前的科学证据，适用于在欧洲大部分地区获批的药物，尤其是德语国家（德国、奥地利和瑞士）。
