Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York.
Cancer Res. 2021 Sep 15;81(18):4673-4675. doi: 10.1158/0008-5472.CAN-21-1407. Epub 2021 Aug 24.
The paradigm of metastasis has been significantly remodeled by the incorporation of cancer dormancy as a mechanism to explain long-term remission intervals followed by relapse. There is overall consensus on the potential impact of better understanding dormancy. Key cancer-cell autonomous and microenvironmental mechanisms might explain this biology and, in turn, the timing of metastasis. However, the approach and feasibility to apply this biology to clinical trials has been controversial. The discussion here provides insight into how these controversies are being resolved by the development of active clinical trials, thus bringing to reality opportunities to target cancer dormancy.
转移的范式已经通过将癌症休眠纳入其中进行了重大重塑，作为解释长期缓解期后复发的一种机制。人们普遍认为更好地理解休眠具有潜在影响。关键的癌细胞自主和微环境机制可能解释这种生物学，进而解释转移的时间。然而，将这种生物学应用于临床试验的方法和可行性一直存在争议。本文讨论了通过开展积极的临床试验如何解决这些争议，从而为靶向癌症休眠带来现实的机会。
