Kong Il Gyu, Rhee Chae-Seo, Lee Jung Woo, Yim Hyojin, Kim Min Jung, Choi Yunhee, Han Doo Hee
Department of Otorhinolaryngology, Hospital Medicine Center, Seoul National University Hospital, Seoul 03080, Korea.
Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul 03080, Korea.
J Clin Med. 2021 Aug 19;10(16):3680. doi: 10.3390/jcm10163680.
Allergic rhinitis (AR), a common chronic disease, impairs patients' quality of life (QoL). This study aimed to determine the effect of perceived stress on disease-related QoL in AR patients. There were 741 patients from eight medical centers of the Allergic Rhinitis Cohort (ARCO) study. Data on sociodemographics, chronic conditions, AR severity, perceived stress level and Rhinoconjunctivitis QoL Questionnaire (RQLQ) results, and laboratory test findings were collected. The relationship between perceived stress and total RQLQ was analyzed using multiple linear regression. Potential confounding variables were adjusted. A high perceived stress level was associated with a high total RQLQ, which reflected worsening disease-related QoL. The high stress level was associated with an increased total RQLQ of 1.210 (95% confidence interval, 0.831-1.589; < 0.0001) compared with the very low level. In the final model, the multiple regression-adjusted R for RQLQ in AR participants was 0.5279, and perceived stress levels contributed 4.08% in additional explanatory power to RQLQ in AR patients. In conclusion, perceived stress is a potentially modifiable risk factor for decreased disease-related QoL in patients with AR, which may be improved with stress management.
变应性鼻炎（AR）是一种常见的慢性疾病，会损害患者的生活质量（QoL）。本研究旨在确定感知压力对AR患者疾病相关生活质量的影响。变应性鼻炎队列（ARCO）研究的八个医学中心共有741名患者。收集了关于社会人口统计学、慢性疾病、AR严重程度、感知压力水平和鼻结膜炎生活质量问卷（RQLQ）结果以及实验室检查结果的数据。使用多元线性回归分析感知压力与RQLQ总分之间的关系，并对潜在的混杂变量进行了调整。高感知压力水平与高RQLQ总分相关，这反映出疾病相关生活质量恶化。与极低压力水平相比，高压力水平与RQLQ总分增加1.210相关（95%置信区间，0.831 - 1.589；P < 0.0001）。在最终模型中，AR参与者RQLQ的多元回归调整R值为0.5279，感知压力水平对AR患者RQLQ的额外解释力贡献为4.08%。总之，感知压力是AR患者疾病相关生活质量下降的一个潜在可改变的危险因素，通过压力管理可能会得到改善。
