Arthritis Clinical and Research Center, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing 100044, China.
Arthritis Institute, Peking University, Beijing 100044, China.
Molecules. 2021 Aug 17;26(16):4987. doi: 10.3390/molecules26164987.
Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a tremendous burden on the health care system worldwide. Although cell therapy has made significant progress in the treatment of OA and cartilage regeneration, there are still a series of problems. Recently, more and more evidence shows that extracellular vesicles (EVs) play an important role in the progression and treatment of OA. Here, we discuss that EVs from different cell sources not only participate in OA progression, but can also be used as effective tools for the diagnosis and treatment of OA. In addition, cell pretreatment strategies and EV tissue engineering play an increasingly prominent role in the field of OA treatment. This article will systematically review the latest developments in these areas. As stated above, it may provide new insights for improving OA and cartilage regeneration.
骨关节炎（OA）是一种影响整个关节的退行性关节疾病，已成为全球医疗保健系统的巨大负担。尽管细胞疗法在 OA 和软骨再生的治疗方面取得了重大进展，但仍存在一系列问题。最近，越来越多的证据表明，细胞外囊泡（EVs）在 OA 的进展和治疗中发挥着重要作用。在这里，我们讨论了来自不同细胞来源的 EVs 不仅参与 OA 的进展，而且还可以作为 OA 的诊断和治疗的有效工具。此外，细胞预处理策略和 EV 组织工程在 OA 治疗领域的作用越来越突出。本文将系统地综述这些领域的最新进展。如前所述，这可能为改善 OA 和软骨再生提供新的见解。
