Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Site Rostock/Greifswald, Ellernholzstr. 1-2, 17489 Greifswald, Germany.
Sport and Exercise Sciences Research Unit, University of Palermo, 90133 Palermo, Italy.
Int J Environ Res Public Health. 2021 Aug 19;18(16):8753. doi: 10.3390/ijerph18168753.
Physical activity (PA) has emerged as an alternative nonpharmacological approach to effectively address the effects of dementia. The primary aim was to identify and summarize PA interventions and their effects on cognitive function among persons with dementia (PwD).
A systematic review was conducted with a meta-analysis using different electronic databases, such as PubMed, Embase, APA PsycNET, and the Web of Science. The identified and selected studies were randomized controlled trials (RCTs) that were written in English, published between 2000 and 2020, and implemented among PwD who received a PA intervention and whose cognitive function was measured at baseline and during a follow-up.
Twenty-two PA intervention studies met the eligibility criteria and showed a medium-size effect on the cognitive function of PwD, 0.4803 (95% CI = 0.1901-0.7704), with a high percentage of heterogeneity (I = 86%, ≤ 0.0001). Moreover, this review complements other reviews by including eight studies that have not previously been considered. Overall, studies have methodological limitations. However, six studies implemented in the past five years have shown more robust methodological designs, including larger sample sizes and more comprehensive measurement tools.
It is not yet possible to draw a conclusion on the ideal PA intervention for this population due to the high proportion of heterogeneity within the included studies. More emphasis is needed on the intensity of PA monitoring and adherence to such programs.
身体活动（PA）已成为一种有效的非药物干预手段，可以有效改善痴呆症的影响。主要目的是确定和总结针对痴呆症患者（PwD）的身体活动干预措施及其对认知功能的影响。
采用系统评价方法，结合文献检索，对不同电子数据库（如 PubMed、Embase、APA PsycNET 和 Web of Science）进行检索。本研究纳入的研究为 2000 年至 2020 年间发表的、以英语撰写的、针对 PwD 实施的、包含身体活动干预且基线和随访时均测量认知功能的随机对照试验（RCT）。
符合纳入标准的 22 项身体活动干预研究显示，对 PwD 的认知功能有中等程度的影响，效应量为 0.4803（95%CI=0.1901-0.7704），异质性较高（I=86%，≤0.0001）。此外，本研究通过纳入其他综述未考虑的 8 项研究，对其他综述进行了补充。总体而言，这些研究存在方法学局限性。但过去 5 年中开展的 6 项研究具有更稳健的方法学设计，包括更大的样本量和更全面的测量工具。
由于纳入研究的高度异质性，目前尚无法确定针对该人群的理想身体活动干预措施。需要更加重视身体活动监测的强度和对这些方案的坚持。
Zotero 插件
