State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Nutrients. 2021 Jul 28;13(8):2592. doi: 10.3390/nu13082592.
Threonine (Thr), an essential amino acid for animals and the limiting amino acid in swine and poultry diets, which plays a vital role in the modulation of nutritional metabolism, macromolecular biosynthesis, and gut homeostasis. Current evidence supports that the supplementation of Thr leads to benefits in terms of energy metabolism. Threonine is not only an important component of gastrointestinal mucin, but also acts as a nutritional modulator that influences the intestinal immune system via complex signaling networks, particularly mitogen-activated protein kinase (MAPK) and the target of the rapamycin (TOR) signal pathway. Threonine is also recognized as an indispensable nutrient for cell growth and proliferation. Hence, optimization of Thr requirement may exert a favorable impact on the factors linked to health and diseases in animals. This review focuses on the latest reports of Thr in metabolic pathways and nutritional regulation, as well as the relationship between Thr and relevant physiological functions.
苏氨酸（Thr）是动物必需的氨基酸，也是猪和家禽饲料中的限制氨基酸，在调节营养代谢、大分子生物合成和肠道稳态方面发挥着重要作用。目前的证据表明，苏氨酸的补充对能量代谢有益。苏氨酸不仅是胃肠道粘蛋白的重要组成部分，而且还作为一种营养调节剂，通过复杂的信号网络影响肠道免疫系统，特别是丝裂原激活蛋白激酶（MAPK）和雷帕霉素靶蛋白（TOR）信号通路。苏氨酸也被认为是细胞生长和增殖所必需的营养物质。因此，优化苏氨酸的需求可能会对动物健康和疾病相关因素产生有利影响。本综述重点介绍了苏氨酸在代谢途径和营养调节方面的最新研究进展，以及苏氨酸与相关生理功能的关系。
