Department of Bromatology, Poznan University of Medical Sciences, 42 Marcelińska Street, 60-354 Poznań, Poland.
Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781 Poznań, Poland.
Nutrients. 2021 Aug 13;13(8):2774. doi: 10.3390/nu13082774.
Vitamin D deficiency is a global problem with many health consequences, and it is currently recommended to supplement vitamin D. Change of diet should also be considered to ensure adequate vitamin D in the human body. The aim of this study was to assess the concentration of vitamin D metabolites in two different groups: one group on the low-carbohydrate-high-fat (LCHF) diet and the other group on the Eastern European (EE) diet. In the first stage, 817 participants declaring traditional EE diet or LCHF diet were investigated. Nutrition (self-reported 3-day estimated food record) and basic anthropometric parameters were assessed. After extra screening, 67 participants on the EE diet and 41 on the LCHF diet were qualified for the second stage. Plasma 25-hydroxycholecalciferol (25(OH)D) and (25(OH)D) concentration was measured by the validated HPLC-MS/MS method. Plasma 25(OH)D concentration was significantly higher in the group on the LCHF diet (34.9 ± 15.9 ng/mL) than in the group on the EE diet (22.6 ± 12.1 ng/mL). No statistical differences were observed in plasma 25(OH)D concentration between the study groups ( > 0.05). Women had a higher plasma 25(OH)D concentration than men regardless of diet type. The LCHF diet had a positive influence on plasma vitamin D concentration. However, long-term use of the LCHF diet remains contentious due to the high risk of cardiovascular disease. This study confirmed that the type of diet influences the concentration of vitamin D metabolites in the plasma.
维生素 D 缺乏是一个全球性问题，会导致许多健康后果，目前建议补充维生素 D。还应考虑改变饮食，以确保人体摄入足够的维生素 D。本研究旨在评估两组人群中维生素 D 代谢物的浓度：一组为低碳水化合物高脂肪（LCHF）饮食组，另一组为东欧（EE）饮食组。在第一阶段，研究了 817 名声称采用传统 EE 饮食或 LCHF 饮食的参与者。评估了营养（自我报告的 3 天估计食物记录）和基本人体测量参数。经过额外筛选，有 67 名 EE 饮食者和 41 名 LCHF 饮食者符合第二阶段的要求。采用经过验证的 HPLC-MS/MS 方法测量血浆 25-羟胆钙化醇（25（OH）D）和（25（OH）D）浓度。LCHF 饮食组的血浆 25（OH）D 浓度（34.9 ± 15.9 ng/mL）显著高于 EE 饮食组（22.6 ± 12.1 ng/mL）。两组间血浆 25（OH）D 浓度无统计学差异（> 0.05）。无论饮食类型如何，女性的血浆 25（OH）D 浓度均高于男性。LCHF 饮食对血浆维生素 D 浓度有积极影响。然而，由于心血管疾病的高风险，长期使用 LCHF 饮食仍存在争议。本研究证实，饮食类型会影响血浆中维生素 D 代谢物的浓度。
