State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.
School of Mechanical Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
Adv Sci (Weinh). 2022 Jul;9(21):e2201291. doi: 10.1002/advs.202201291. Epub 2022 May 26.
The left ventricular assist device (LVAD) is often used in the treatment of heart failure. However, 4% to 9% implanted LVAD will have thrombosis problem in one year, which is fatal to the patient's life. In this work, an interventional sonothrombolysis (IST) method is developed to realize the thrombolysis on LVAD. A pair of ultrasound transducer rings is installed on the shell of LVAD, and drug-loaded microbubbles are injected into the LVAD through the interventional method. The microbubbles are adhere on the thrombus with the coated thrombus-targeted drugs, and the thrombolytic drugs carried by the bubbles are brought into the thrombus by the cavitation of bubbles under the ultrasound. In a proof-of-concept experiment in a live sheep model, the thrombus on LVAD is dissolved in 30 min, without damages on LVADs and organs. This IST exhibits to be more efficient and safer compared with other thrombolysis methods on LVAD.
左心室辅助装置（LVAD）常用于心力衰竭的治疗。然而，植入的 LVAD 中有 4%至 9%会在一年内出现血栓问题，这对患者的生命是致命的。在这项工作中，开发了一种介入超声溶栓（IST）方法来实现 LVAD 的溶栓。一对超声换能器环安装在 LVAD 的外壳上，并通过介入方法将载药微泡注入 LVAD。微泡与涂有血栓靶向药物的血栓结合，并在超声下的空化作用下将气泡携带的溶栓药物带入血栓中。在活体羊模型中的概念验证实验中，LVAD 上的血栓在 30 分钟内溶解，LVAD 和器官均未受损。与其他 LVAD 溶栓方法相比，这种 IST 显示出更高的效率和安全性。
