Abdelghafour Mohamed M, Orbán Ágoston, Deák Ágota, Lamch Łukasz, Frank Éva, Nagy Roland, Ádám Adél, Sipos Pál, Farkas Eszter, Bari Ferenc, Janovák László
Department of Physical Chemistry and Materials Science, University of Szeged, Rerrich Béla tér 1, H-6720 Szeged, Hungary.
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt.
Polymers (Basel). 2021 Aug 15;13(16):2725. doi: 10.3390/polym13162725.
Poly(ethylene succinate) (PES) is one of the most promising biodegradable and biocompatible polyesters and is widely used in different biomedical applications. However, little information is available on its solubility and precipitation properties, despite that these solution behavior properties affect its applicability. In order to systematically study these effects, biodegradable and biocompatible poly(ethylene succinate) (PES) was synthesized using ethylene glycol and succinic acid monomers with an equimolar ratio. Despite the optimized reaction temperature (T = 185 °C) of the direct condensation polymerization, relatively low molecular mass values were achieved without using a catalyst, and the was adjustable with the reaction time (40-100 min) in the range of ~850 and ~1300 Da. The obtained crude products were purified by precipitation from THF ("good" solvent) with excess of methanol ("bad" solvent). The solvents for PES oligomers purification were chosen according to the calculated values of solubility parameters by different approaches (Fedors, Hoy and Hoftyzer-van Krevelen). The theta-solvent composition of the PES solution was 0.3 v/v% water and 0.7 v/v% DMSO in this binary mixture. These measurements were also allowed to determine important parameters such as the coefficients A (=0.67) and B (=3.69 × 10) from the Schulz equation, or the (=8.22 × 10) and α (=0.52) constants from the Kuhn-Mark-Houwink equation. Hopefully, the prepared PES with different molecular weights is a promising candidate for biomedical applications and the reported data and constants are useful for other researchers who work with this promising polyester.
聚琥珀酸乙二酯（PES）是最具前景的可生物降解且生物相容的聚酯之一，广泛应用于不同的生物医学领域。然而，尽管其溶液行为特性会影响其适用性，但关于其溶解性和沉淀特性的信息却很少。为了系统地研究这些影响，使用等摩尔比的乙二醇和琥珀酸单体合成了可生物降解且生物相容的聚琥珀酸乙二酯（PES）。尽管直接缩聚反应的优化温度为T = 185 °C，但在不使用催化剂的情况下，得到的分子量相对较低，并且其分子量可在约850至约1300 Da的范围内随反应时间（40 - 100分钟）进行调节。通过用过量的甲醇（“不良”溶剂）从四氢呋喃（“良好”溶剂）中沉淀来纯化所得的粗产物。根据通过不同方法（费多斯法、霍伊法和霍夫蒂泽 - 范克雷维伦法）计算的溶解度参数值来选择用于纯化PES低聚物的溶剂。在该二元混合物中，PES溶液的θ溶剂组成为0.3 v/v%的水和0.7 v/v%的二甲基亚砜（DMSO）。这些测量还使得能够从舒尔茨方程确定重要参数，如系数A（= 0.67）和B（= 3.69×10），或从库恩 - 马克 - 豪温克方程确定常数K（= 8.22×10）和α（= 0.52）。有望地，制备的不同分子量的PES是生物医学应用的有前景的候选材料，并且所报道的数据和常数对其他研究这种有前景的聚酯的研究人员有用。
