用于骨组织工程应用的、由纳米羟基磷灰石和/或氧化石墨烯增强的合成可生物降解脂肪族聚酯纳米复合材料。

Synthetic Biodegradable Aliphatic Polyester Nanocomposites Reinforced with Nanohydroxyapatite and/or Graphene Oxide for Bone Tissue Engineering Applications.

作者信息

Li Yuchao, Liao Chengzhu, Tjong Sie Chin

机构信息

Department of Materials Science and Engineering, Liaocheng University, Liaocheng 252059, China.

Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China.

出版信息

Nanomaterials (Basel). 2019 Apr 10;9(4):590. doi: 10.3390/nano9040590.

Abstract

This paper provides review updates on the current development of bionanocomposites with polymeric matrices consisting of synthetic biodegradable aliphatic polyesters reinforced with nanohydroxyaptite (nHA) and/or graphene oxide (GO) nanofillers for bone tissue engineering applications. Biodegradable aliphatic polyesters include poly(lactic acid) (PLA), polycaprolactone (PCL) and copolymers of PLA-PGA (PLGA). Those bionanocomposites have been explored for making 3D porous scaffolds for the repair of bone defects since nHA and GO enhance their bioactivity and biocompatibility by promoting biomineralization, bone cell adhesion, proliferation and differentiation, thus facilitating new bone tissue formation upon implantation. The incorporation of nHA or GO into aliphatic polyester scaffolds also improves their mechanical strength greatly, especially hybrid GO/nHA nanofilllers. Those mechanically strong nanocomposite scaffolds can support and promote cell attachment for tissue growth. Porous scaffolds fabricated from conventional porogen leaching, and thermally induced phase separation have many drawbacks inducing the use of organic solvents, poor control of pore shape and pore interconnectivity, while electrospinning mats exhibit small pores that limit cell infiltration and tissue ingrowth. Recent advancement of 3D additive manufacturing allows the production of aliphatic polyester nanocomposite scaffolds with precisely controlled pore geometries and large pores for the cell attachment, growth, and differentiation in vitro, and the new bone formation in vivo.

摘要

本文提供了关于生物纳米复合材料当前发展的综述更新,这些生物纳米复合材料具有由合成可生物降解脂肪族聚酯组成的聚合物基质,并用纳米羟基磷灰石(nHA)和/或氧化石墨烯(GO)纳米填料增强,用于骨组织工程应用。可生物降解脂肪族聚酯包括聚乳酸(PLA)、聚己内酯(PCL)以及PLA - PGA共聚物(PLGA)。由于nHA和GO通过促进生物矿化、骨细胞粘附、增殖和分化来增强其生物活性和生物相容性,从而在植入后促进新骨组织形成,因此已经探索了那些生物纳米复合材料来制造用于修复骨缺损的三维多孔支架。将nHA或GO掺入脂肪族聚酯支架中也极大地提高了它们的机械强度,尤其是混合的GO/nHA纳米填料。那些机械强度高的纳米复合支架可以支持并促进细胞附着以促进组织生长。由传统致孔剂浸出和热致相分离制备的多孔支架有许多缺点,包括使用有机溶剂、对孔形状和孔互连性控制不佳,而静电纺丝垫具有小孔隙,限制了细胞浸润和组织向内生长。三维增材制造的最新进展使得能够生产具有精确控制的孔几何形状和大孔隙的脂肪族聚酯纳米复合支架,用于体外细胞附着、生长和分化以及体内新骨形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cd8/6523566/f6032f5a2962/nanomaterials-09-00590-g001.jpg

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