Capponi Pier Cesare, Murri Domenico, Pernice Carmine
Radiopharmaceutical Chemistry Section, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Otolaryngology Unit, Department of Surgery, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Pharmaceutics. 2021 Aug 4;13(8):1201. doi: 10.3390/pharmaceutics13081201.
L-ascorbic acid, is a well-known molecule, sometimes used as antioxidant for skin care. Nonetheless, few studies have taken in account its utility as topical treatment for non-melanoma skin vancer. Non-melanoma skin cancer includes basal cell carcinoma and squamous cell carcinoma and is widespread worldwide with an increasing incidence. The purpose of this paper is to analyze the characteristics of L-ascorbic acid topical formulation, its percutaneous absorption and biochemical mechanism, focusing on its anti-cancer properties. In particular, it will be described how the pH and the concentration of the formulation are able to influence its distribution in the skin and tissues. We will report, the current knowledge on the pharmacokinetic aspects of L-ascorbic acid that allows us to reconsider it in the light of its ability to act as a prodrug and as an anticancer agent. Lastly, a short review with the aim to find any evidence of a possible clinical use of L-ascorbic acid for the treatment of non-melanoma skin cancer was made.
L-抗坏血酸是一种知名的分子，有时用作护肤品中的抗氧化剂。然而，很少有研究考虑到它作为非黑色素瘤皮肤癌局部治疗药物的效用。非黑色素瘤皮肤癌包括基底细胞癌和鳞状细胞癌，在全球范围内广泛存在且发病率不断上升。本文的目的是分析L-抗坏血酸局部制剂的特性、其经皮吸收和生化机制，重点关注其抗癌特性。特别是，将描述制剂的pH值和浓度如何影响其在皮肤和组织中的分布。我们将报告关于L-抗坏血酸药代动力学方面的现有知识，这使我们能够根据其作为前药和抗癌剂的作用能力重新审视它。最后，进行了一项简短的综述，旨在寻找L-抗坏血酸治疗非黑色素瘤皮肤癌可能的临床应用证据。
