Higuera-Domínguez Fátima, Ochoa-Díaz-López Héctor, Irecta-Nájera César Antonio, Núñez-Ortega Pilar E, Castro-Quezada Itandehui, García-Miranda Rosario, Solís-Hernández Roberto, García-Parra Esmeralda, Ruiz-López María Dolores
Health Department, El Colegio de la Frontera Sur, Carr. A Reforma Km. 15.5 s/n, RA. Guineo 2da. Sección, Villahermosa 86280, Mexico.
Faculty of Nutrition and Food Science, University of Science and Arts of Chiapas, Libramiento Norte-Poniente 1150, Col Lajas Maciel, Tuxtla Gutiérrez 29039, Mexico.
Nutrients. 2025 Jan 11;17(2):254. doi: 10.3390/nu17020254.
The presence of malnutrition in early life is a determining factor in the onset of metabolic alterations and chronic diseases in adults. Therefore, the objective of this study was to determine the impact of malnutrition in early childhood with the presence of cardiometabolic risk factors in adulthood in marginalized populations from Chiapas, Mexico. The present investigation was based on a prospective cohort study that began in 2002, with young adults aged 18 to 25 years belonging to region in Chiapas, Mexico. Sociodemographic, anthropometric, clinical and biochemical data were obtained in adulthood. Binary logistic regression models with 95% confidence intervals were fitted to assess the association between nutritional status in childhood (≤5 years of age) and cardiometabolic risk in adulthood. Individuals with overweight/obesity in childhood were more likely to have overweight/obesity (OR = 2.65, 95% CI: 1.09-6.45), high waist circumference (3.78, 95% CI: 1.55-9.24), high waist to height ratio (OR = 5.38, CI 95%: 1.60-18.10), elevated total cholesterol (OR = 3.95, 95% CI: 1.36-11.43) and metabolic syndrome (OR = 4.71, 95% CI: 1.49-14.90) in adulthood. In conclusion, malnutrition presented in early childhood increased the probability of developing cardiometabolic alterations in young adults from southern Mexico.
生命早期营养不良是成人代谢改变和慢性病发病的决定性因素。因此，本研究的目的是确定墨西哥恰帕斯州边缘化人群中儿童早期营养不良对成年期心血管代谢危险因素的影响。本调查基于一项始于2002年的前瞻性队列研究，研究对象为墨西哥恰帕斯州某地区18至25岁的年轻人。在成年期获取了社会人口统计学、人体测量学、临床和生化数据。采用95%置信区间的二元逻辑回归模型来评估儿童期（≤5岁）营养状况与成年期心血管代谢风险之间的关联。儿童期超重/肥胖的个体成年后更有可能出现超重/肥胖（比值比=2.65，95%置信区间：1.09-6.45）、高腰围（3.78，95%置信区间：1.55-9.24）、高腰高比（比值比=5.38，95%置信区间：1.60-18.10）、总胆固醇升高（比值比=3.95，95%置信区间：1.36-11.43）和代谢综合征（比值比=4.71，95%置信区间：1.49-14.90）。总之，墨西哥南部儿童期出现的营养不良增加了年轻成人发生心血管代谢改变的可能性。
