Huang X, He D, Pan Z, Luo G, Deng J
Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Army Medical University, 400038 Chongqing, China.
Department of Endocrinology and Nephrology, The Seventh People's Hospital of Chongqing.
Mater Today Bio. 2021 Jul 24;11:100124. doi: 10.1016/j.mtbio.2021.100124. eCollection 2021 Jun.
Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-accumulation of ROS causes premature aging and/or death and is associated with various inflammatory conditions. Nevertheless, there are limited clinical treatment options that are currently available. The good news is that owing to the considerable advances in nanoscience, multiple types of nanomaterials with unique ROS-scavenging abilities that influence the temporospatial dynamic behaviors of ROS in biological systems have been developed. This has led to the emergence of next-generation nanomaterial-controlled strategies aimed at ameliorating ROS-related inflammatory conditions. Accordingly, herein we reviewed recent progress in research on nanotherapy based on ROS scavenging. The underlying mechanisms of the employed nanomaterials are emphasized. Furthermore, important issues in developing cross-disciplinary nanomedicine-based strategies for ROS-based inflammatory conditions are discussed. Our review of this increasing interdisciplinary field will benefit ongoing studies and clinical applications of nanomedicine based on ROS scavenging.
活性氧（ROS）介导多种生理功能；然而，ROS的过度积累会导致早衰和/或死亡，并与各种炎症状态相关。尽管如此，目前可用的临床治疗选择有限。好消息是，由于纳米科学的显著进展，已开发出多种具有独特ROS清除能力的纳米材料，这些能力会影响生物系统中ROS的时空动态行为。这导致了旨在改善ROS相关炎症状态的下一代纳米材料控制策略的出现。因此，在此我们综述了基于ROS清除的纳米治疗研究的最新进展。重点强调了所采用纳米材料的潜在机制。此外，还讨论了为基于ROS的炎症状态开发跨学科纳米医学策略中的重要问题。我们对这个日益跨学科领域的综述将有益于基于ROS清除的纳米医学的 ongoing研究和临床应用。
原文中“ongoing studies”直译为“正在进行的研究”，但在中文语境中“ongoing”可意译为“持续的”，整体表述会更通顺自然，即“持续研究” 。上述翻译已按此调整。
