烟酰胺甲基转移酶的作用机制与抑制剂
Mechanisms and inhibitors of nicotinamide -methyltransferase.
作者信息
Iyamu Iredia D, Huang Rong
机构信息
Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Institute for Drug Discovery, Purdue University West Lafayette Indiana 47907 USA
出版信息
RSC Med Chem. 2021 May 19;12(8):1254-1261. doi: 10.1039/d1md00016k. eCollection 2021 Aug 18.
Abstract
Nicotinamide -methyltransferase (NNMT) plays an important role in diverse biological processes by regulating methylation potential and the degradation of nicotinamide. Meanwhile, the aberrant expression of NNMT has been implicated in multiple cancers, metabolic and liver diseases. Therefore, there has been an emerging interest in assessing NNMT as a potential therapeutic target and discovering NNMT inhibitors over the past 5 years. Herein, we focus on the recognition, mechanism, and inhibitors of NNMT with emphasis on key advancements in the field. We also discuss future directions for the development of NNMT inhibitors.
摘要
烟酰胺甲基转移酶（NNMT）通过调节甲基化潜能和烟酰胺的降解，在多种生物学过程中发挥重要作用。同时，NNMT的异常表达与多种癌症、代谢性疾病和肝脏疾病有关。因此，在过去5年里，人们对评估NNMT作为潜在治疗靶点以及发现NNMT抑制剂的兴趣日益浓厚。在此，我们重点关注NNMT的识别、作用机制和抑制剂，着重介绍该领域的关键进展。我们还讨论了NNMT抑制剂开发的未来方向。
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