自由呼吸肺部磁共振弹性成像：一项活体研究。
Free-breathing MR elastography of the lungs: An in vivo study.
机构信息
Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
出版信息
Magn Reson Med. 2022 Jan;87(1):236-248. doi: 10.1002/mrm.28986. Epub 2021 Aug 31.
PURPOSE
Lung stiffness alters with many diseases; therefore, several MR elastography (MRE) studies were performed earlier to investigate the stiffness of the right lung during breathhold at residual volume and total lung capacity. The aims of this study were 1) to estimate shear stiffness of the lungs using MRE under free breathing and demonstrate the measurements' repeatability and reproducibility, and 2) to compare lung stiffness under free breathing to breathhold and as a function of age and gender.
METHODS
Twenty-five healthy volunteers were scanned on a 1.5 Tesla MRI scanner. Spin-echo dual-density spiral and a spin-echo EPI MRE sequences were used to measure shear stiffness of the lungs during free breathing and breathhold at midpoint of tidal volume, respectively. Concordance correlation coefficient and Bland-Altman analyses were performed to determine the repeatability and reproducibility of the spin-echo dual-density spiral-derived shear stiffness. Repeated measures analyses of variances were used to investigate differences in shear stiffness between spin-echo dual-density spiral and spin-echo EPI, right and left lungs, males and females, and different age groups.
RESULTS
Free-breathing MRE sequence was highly repeatable and reproducible (concordance correlation coefficient > 0.86 for both lungs). Lung stiffness was significantly lower in breathhold than in free breathing (P < .001), which can be attributed to potential stress relaxation of lung parenchyma or breathhold inconsistencies. However, there was no significant difference between different age groups (P = .08). The left lung showed slightly higher stiffness values than the right lung (P = .14). There is no significant difference in lung stiffness between genders.
CONCLUSION
This study demonstrated the feasibility of free-breathing lung MRE with excellent repeatability and reproducibility. Stiffness changes with age and during the respiratory cycle. However, gender does not influence lungs stiffness.
目的
肺部僵硬度会随多种疾病而改变；因此，之前有几项磁共振弹性成像（MRE）研究旨在探究在残气量和肺总量时屏气状态下右肺的僵硬度。本研究的目的是：1）使用 MRE 在自由呼吸下评估肺部剪切弹性，并展示测量的可重复性和再现性，2）比较自由呼吸、屏气和年龄、性别对肺僵硬度的影响。
方法
25 名健康志愿者在 1.5T MRI 扫描仪上进行扫描。使用自旋回波双密度螺旋和自旋回波 EPI MRE 序列分别在自由呼吸和潮气末中点屏气时测量肺部的剪切弹性。采用一致性相关系数和 Bland-Altman 分析来确定自旋回波双密度螺旋衍生剪切弹性的可重复性和再现性。采用重复测量方差分析来研究自旋回波双密度螺旋和自旋回波 EPI、左右肺、男女和不同年龄组之间剪切弹性的差异。
结果
自由呼吸 MRE 序列具有很高的可重复性和再现性（双侧肺的一致性相关系数均>0.86）。与自由呼吸相比，屏气时的肺僵硬度显著降低（P<.001），这可能归因于肺实质的潜在应力松弛或屏气不一致性。然而，不同年龄组之间没有显著差异（P=0.08）。左肺的僵硬度值略高于右肺（P=0.14）。性别对肺僵硬度没有影响。
结论
本研究证明了自由呼吸肺部 MRE 的可行性，具有极好的可重复性和再现性。僵硬度随年龄和呼吸周期而变化。然而，性别并不影响肺部的僵硬度。
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