El-Tarabily Khaled A, El-Saadony Mohamed T, Alagawany Mahmoud, Arif Muhammad, Batiha Gaber E, Khafaga Asmaa F, Elwan Hamada A M, Elnesr Shaaban S, E Abd El-Hack Mohamed
Department of Biology, College of Science, United Arab Emirates University, 15551 Al-Ain, United Arab Emirates.
Harry Butler Institute, Murdoch University, Murdoch 6150, Western Australia, Australia.
Saudi J Biol Sci. 2021 Sep;28(9):5145-5156. doi: 10.1016/j.sjbs.2021.05.033. Epub 2021 May 20.
The increase of resistant bacteria puts a huge pressure on the antimicrobials in current use. Antimicrobial resistance (AMR) results from antibiotic misuse and abuse over many years and is a global financial burden. New polices must be developed for the use of antimicrobials and to continue research efforts to mitigate AMR. It is essential to target the most harmful bacteria and concentrate on their mechanisms of resistance to develop successful antimicrobials. Essential oils (EOs) are occur naturally in plants and have long been used as antimicrobials, but most have not been researched. This review explores EOs as alternative antimicrobials, investigating their ability to decrease or inhibit biofilm formation, and assess their ability to contribute to AMR control. Low concentrations of EOs can inhibit Gram-positive and Gram-negative pathogenic bacteria. Some EOs have demonstrated strong anti-biofilm activities. If EOs are successful against biofilm formation, particularly in bacteria developing AMR, they could be incorporated into new antimicrobials. Therefore, there is a need to investigate these EOs' potential, particularly for surface disinfection, and against bacteria from food, clinical and non-clinical environments.
耐药菌的增加给当前使用的抗菌药物带来了巨大压力。抗菌药物耐药性（AMR）是多年来抗生素滥用和误用的结果，是一项全球性的财政负担。必须制定新的抗菌药物使用政策，并继续开展研究工作以减轻AMR。针对最有害的细菌并专注于其耐药机制来开发成功的抗菌药物至关重要。精油（EOs）天然存在于植物中，长期以来一直被用作抗菌剂，但大多数尚未得到研究。本综述探讨了精油作为替代抗菌剂的作用，研究它们减少或抑制生物膜形成的能力，并评估它们对控制AMR的贡献。低浓度的精油可以抑制革兰氏阳性和革兰氏阴性病原菌。一些精油已显示出强大的抗生物膜活性。如果精油能成功对抗生物膜形成，特别是在产生AMR的细菌中，它们可以被纳入新的抗菌药物中。因此，有必要研究这些精油的潜力，特别是用于表面消毒以及对抗来自食品、临床和非临床环境中的细菌。
