Jamshidi Sanaz, Hejazi Najmeh, Golmakani Mohammad-Taghi, Tanideh Nader, Heidari Esfahani Mina
Department of Clinical Nutrition, School of Nutrition and food sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Nutrition research center, Department of Clinical Nutrition, School of Nutrition and food sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Galen Med J. 2019 Jan 1;8:e1238. doi: 10.22086/gmj.v8i0.1238. eCollection 2019.
Wild pistachio () species with wide distribution in Iran have different nutrition properties and may have therapeutic effects in metabolic syndrome. Metabolic syndrome, as a prevalent health problem, is a main risk factor for different chronic diseases such as diabetes, fatty liver and cardiovascular diseases. The present study aimed to evaluate the preventive effects of mixture, kernel, and hull oil of wild pistachio (WP) on oxidative stress markers, liver function and histopathological findings in metabolic syndrome induced rats.
After oil extraction by cold press method and chemical analysis, rats were divided into 6 groups. Group 1 received normal saline; group 2 received 2cc fructose solution and 0.5cc normal saline; and groups 3, 4, 5 and 6 received 2 cc fructose solution and 0.5 cc sunflower oil, mixture, hull and kernel oils of WP for 10 weeks, respectively. Then, glycemic indices, oxidative stress, liver enzymes and histopathological examination were determined using standard laboratory tests.
WP Kernel and mixture oils notably decreased the fasting blood sugar and insulin resistance compared with the fructose group. Insulin level was significantly increased in the kernel oil group (P<0.05). There was no significant difference in oxidative stress, liver enzymes and histopathology parameters among the groups.
Kernel oil of WP improved hyperglycemia, insulin resistance and insulin secretion, but the changes in oxidative stress markers, liver enzymes and histopathologic results were not significant among the groups.
在伊朗广泛分布的野生开心果（）品种具有不同的营养特性，可能对代谢综合征具有治疗作用。代谢综合征作为一个普遍的健康问题，是糖尿病、脂肪肝和心血管疾病等不同慢性疾病的主要危险因素。本研究旨在评估野生开心果（WP）混合物、果仁及果壳油对代谢综合征诱导大鼠氧化应激标志物、肝功能及组织病理学结果的预防作用。
通过冷榨法提取油并进行化学分析后，将大鼠分为6组。第1组接受生理盐水；第2组接受2cc果糖溶液和0.5cc生理盐水；第3、4、5和6组分别接受2cc果糖溶液和0.5cc向日葵油、WP混合物、果壳油及果仁油，持续10周。然后，使用标准实验室检测方法测定血糖指数、氧化应激、肝酶及组织病理学检查结果。
与果糖组相比，WP果仁油和混合物油显著降低了空腹血糖和胰岛素抵抗。果仁油组胰岛素水平显著升高（P<0.05）。各组间氧化应激、肝酶及组织病理学参数无显著差异。
WP果仁油改善了高血糖、胰岛素抵抗和胰岛素分泌，但各组间氧化应激标志物、肝酶及组织病理学结果的变化不显著。
