Djerrou Zouhir, Hamdi-Pacha Y, Belkhiri A M, Djaalab H, Riachi F, Serakta M, Boukeloua A, Maameri Z
Department of Veterinary Sciences, Pharmaco toxicology Laboratory, Mentouri Constantine University, Algeria.
Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):214-9. doi: 10.4314/ajtcam.v8i5S.27. Epub 2011 Jul 3.
Pistacia lentiscus fatty oil (PLFO) is a well known natural remedy in eastern Algeria folk medicine. It is widely used in the treatment of respiratory disorders and dermal burns. The present study has been carried out to investigate effects of this oil on fasting glucose and some functional parameters of the liver and kidney in white male New Zealand rabbits (Initial mean weight 1.95 Kg). PLFO was applied to tested rabbits (PLFO group) via rectal route, once daily 5-day per week, for six consecutive weeks at the dose of 1 ml/Kg body weight. The same number of animals (n=6) was not treated and served as control (CRL group). The results showed that PLFO was tolerated by rectal route. No significant differences were observed in body weights of the two groups. Biochemical analysis showed that aspartate transaminase (AST) and alanine transaminase (ALT) were significantly decreased in blood plasma at (P< 0.05) and (P< 0.01) respectively in PLFO group (Mann-Whitney test). On the other hand, the fasting glucose level (GLU) was significantly increased (Mann-Whitney test, P< 0.05), while the rest of the tested parameters (Albumin, total proteins, creatinine, urea) was not significantly affected. However, these variations have not biologic signification toxicity. The study concludes that PLFO is tolerable via rectal route; it is safe with no adverse effect on liver functions and renal functions with possible anti-glycogenesis activity.
乳香黄连木脂肪油（PLFO）是阿尔及利亚东部民间医学中一种著名的天然药物。它广泛用于治疗呼吸系统疾病和皮肤烧伤。本研究旨在探讨该油对雄性新西兰白兔（初始平均体重1.95千克）空腹血糖以及肝脏和肾脏一些功能参数的影响。PLFO通过直肠途径应用于受试兔（PLFO组），每周5天，每天一次，连续六周，剂量为1毫升/千克体重。相同数量的动物（n = 6）未接受治疗，作为对照组（CRL组）。结果表明，PLFO通过直肠途径可耐受。两组动物体重未观察到显著差异。生化分析表明，PLFO组血浆中天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）分别显著降低（P < 0.05）和（P < 0.01）（曼-惠特尼检验）。另一方面，空腹血糖水平（GLU）显著升高（曼-惠特尼检验，P < 0.05），而其余受试参数（白蛋白、总蛋白、肌酐、尿素）未受到显著影响。然而，这些变化没有生物学意义上的毒性。该研究得出结论，PLFO通过直肠途径可耐受；它是安全的，对肝功能和肾功能无不良影响，可能具有抗糖原生成活性。
