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水稻与稻黄单胞菌互作的适应性进化：种间二维 GWAS 揭示了其遗传基础。

Reciprocal adaptation of rice and Xanthomonas oryzae pv. oryzae: cross-species 2D GWAS reveals the underlying genetics.

机构信息

Institute of Crop Sciences/National Key Facility for Crop Gene Resources and Genetic Improvement, Chinese Academy of Agricultural Sciences, 12 South Zhong-Guan-Cun Street, Haidian District, Beijing 100081, China.

College of Agronomy, Anhui Agricultural University, 130 West Chang-Jiang Street, Hefei 230036, China.

出版信息

Plant Cell. 2021 Aug 31;33(8):2538-2561. doi: 10.1093/plcell/koab146. Epub 2021 Jun 2.

DOI:10.1093/plcell/koab146
PMID:34467412
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8408478/
Abstract

A 1D/2D genome-wide association study strategy was adopted to investigate the genetic systems underlying the reciprocal adaptation of rice (Oryza sativa) and its bacterial pathogen, Xanthomonas oryzae pv. oryzae (Xoo) using the whole-genome sequencing and large-scale phenotyping data of 701 rice accessions and 23 diverse Xoo strains. Forty-seven Xoo virulence-related genes and 318 rice quantitative resistance genes (QR-genes) mainly located in 41 genomic regions, and genome-wide interactions between the detected virulence-related genes and QR genes were identified, including well-known resistance genes/virulence genes plus many previously uncharacterized ones. The relationship between rice and Xoo was characterized by strong differentiation among Xoo races corresponding to the subspecific differentiation of rice, by strong shifts toward increased resistance/virulence of rice/Xoo populations and by rich genetic diversity at the detected rice QR-genes and Xoo virulence genes, and by genome-wide interactions between many rice QR-genes and Xoo virulence genes in a multiple-to-multiple manner, presumably resulting either from direct protein-protein interactions or from genetic epistasis. The observed complex genetic interaction system between rice and Xoo likely exists in other crop-pathogen systems that would maintain high levels of diversity at their QR-loci/virulence-loci, resulting in dynamic coevolutionary consequences during their reciprocal adaptation.

摘要

采用 1D/2D 全基因组关联研究策略，利用 701 份水稻品系和 23 种不同的稻黄单胞菌 pv. 稻种（Xoo）的全基因组测序和大规模表型数据，研究了水稻（Oryza sativa）及其细菌性病原体稻黄单胞菌 pv. 稻种（Xoo）相互适应的遗传系统。鉴定了 47 个与 Xoo 毒力相关的基因和 318 个水稻数量抗性基因（QR-genes），主要位于 41 个基因组区域，检测到的与毒力相关的基因和 QR 基因之间存在全基因组相互作用，包括著名的抗性基因/毒力基因和许多以前未被描述的基因。水稻和 Xoo 之间的关系具有以下特点：Xoo 菌系之间存在强烈分化，对应于水稻亚种分化；水稻/ Xoo 种群的抗性/毒力呈强烈上升趋势；检测到的水稻 QR-genes 和 Xoo 毒力基因具有丰富的遗传多样性；许多水稻 QR-genes 和 Xoo 毒力基因之间存在全基因组相互作用，呈多对多方式，可能是由于直接的蛋白质-蛋白质相互作用或遗传上位性所致。观察到的水稻和 Xoo 之间复杂的遗传相互作用系统可能存在于其他作物-病原体系统中，这些系统在其 QR 基因座/毒力基因座保持高水平的多样性，导致在相互适应过程中产生动态的协同进化后果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12be/8408478/a0a0eb1efdfa/koab146f7.jpg
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