Dietetics and Nutrition Department, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, Florida, USA.
Obes Rev. 2021 Dec;22(12):e13335. doi: 10.1111/obr.13335. Epub 2021 Sep 1.
Recruitment of children into clinical trials is challenging. Most systematic reviews exploring facilitators and barriers of child recruitment in clinical trials are related to drugs or experimental treatments for various health conditions. This may differ in nutrition, physical activity, and obesity interventions. The objective was to conduct a systematic review of facilitators and barriers for children's participation in nutrition, physical activity, and obesity interventions from the perspective of parents, children, and researchers. Studies were identified from five databases and restricted to children 2-18 years and the English language. Studies without results on facilitators and barriers of recruitment were excluded. Four hundred twenty-three records were identified; 94 duplicates and 269 unrelated records were initially excluded; 60 records were reviewed for full-text, and subsequently 34 were excluded, for a total of 26 included studies. The top barriers for recruiting children into clinical trials were time constraints, understanding of clinical trial information or complexity of consent/trial info, and transportation/lack of childcare. The most common facilitators were benefits to others and self, compensation/incentives, physician recommendations/referrals, and support. These barriers and facilitators should be addressed in future studies to assist in the successful recruitment of children into nutrition, physical activity, and obesity interventions.
招募儿童参与临床试验具有挑战性。大多数探索临床试验中儿童招募促进因素和障碍的系统评价都与各种健康状况的药物或实验性治疗有关。在营养、身体活动和肥胖干预方面可能有所不同。本研究旨在从家长、儿童和研究人员的角度对营养、身体活动和肥胖干预措施中儿童参与的促进因素和障碍进行系统评价。研究从五个数据库中确定，并仅限于 2-18 岁的儿童和英语。排除未报告招募促进因素和障碍结果的研究。共确定了 423 条记录；最初排除了 94 条重复和 269 条不相关的记录；对 60 篇全文进行了回顾，随后排除了 34 篇，共有 26 篇纳入研究。招募儿童参加临床试验的最大障碍是时间限制、对临床试验信息的理解或同意/试验信息的复杂性以及交通/缺乏儿童保育。最常见的促进因素是对他人和自己的益处、补偿/激励、医生的建议/推荐以及支持。在未来的研究中，应解决这些障碍和促进因素，以帮助成功招募儿童参与营养、身体活动和肥胖干预。
