番石榴的化学成分及其抗肿瘤和抗真菌活性

[Chemical constituents of Psidium guajava and their antitumor and antifungal activities].

作者信息

Liu Xiao-Cong, Lin Dong-Mei, Liu Min, Zhang Min, Li Qiang, Wang Jian, Xu Lu-Lin, Gao Yuan, Yang Jian

机构信息

Faculty of Materials and Chemical Engineering, Yibin University Yibin 644000, China.

State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2021 Aug;46(15):3877-3885. doi: 10.19540/j.cnki.cjcmm.20210517.202.

DOI:10.19540/j.cnki.cjcmm.20210517.202

PMID:34472263

Abstract

Twenty-six compounds, including sixteen meroterpenoids(1-16), a triterpenoid(17), four terpenoid derivatives(18-21), and five aromatic compounds(22-26), were isolated from the leaves of Psidium guajava. Their structures were identified by spectroscopic analyses including NMR and MS. Compounds 21-26 were obtained from plants of Psidium for the first time. Based on the structure,(R)-2-ethylhexyl 2H-1,2,3-triazole-4-carboxylate(24 a), an α-glucosidase inhibitor recently isolated from Paramignya trimera, should be revised as compound 24. Meroterpenoids 1-16 were evaluated for their antitumor and antifungal activities. Meroterpenoids psiguajadial D(4), guapsidial A(5), 4,5-diepipsidial A(7), guadial A(14), and guadial B(15) showed cytotoxicities against five human tumor cell lines(HL-60, A-549, SMMC-7721, MCF-7, and SW-480), among which 5 was the most effective with an IC_(50) of 3.21-9.94 μmol·L~(-1).

摘要

从番石榴叶中分离出26种化合物，包括16种半萜（1-16）、1种三萜（17）、4种萜类衍生物（18-21）和5种芳香化合物（22-26）。通过包括核磁共振（NMR）和质谱（MS）在内的光谱分析确定了它们的结构。化合物21-26首次从番石榴属植物中获得。基于结构，最近从三裂帕拉木尼亚中分离出的α-葡萄糖苷酶抑制剂（R）-2-乙基己基2H-1,2,3-三唑-4-羧酸酯（24 a）应修订为化合物24。对半萜1-16进行了抗肿瘤和抗真菌活性评估。半萜番石榴二醛D（4）、番石榴醛A（5）、4,5-二表番石榴醛A（7）、番石榴醛A（14）和番石榴醛B（15）对5种人类肿瘤细胞系（HL-60、A-549、SMMC-7721、MCF-7和SW-480）显示出细胞毒性，其中5最有效，IC50为3.21-9.94 μmol·L-1。