He Tiefei, Yuan Chendong, Zhao Cansong
Department of Vascular Surgery, Zhuji Affiliated Hospital of Shaoxing University, Zhuji, Zhejiang 311800, China.
Biomed Pharmacother. 2021 Nov;143:112127. doi: 10.1016/j.biopha.2021.112127. Epub 2021 Aug 30.
Cancer involves complex etiology factors, multiple stages, and intricate gene mutations. Long non-coding RNAs (lncRNAs) are implicated as molecular mechanisms underlying human genomic activity in various physiologic and pathophysiologic conditions. However, the sophisticated modifications and regulatory processes linking lncRNAs to cancer initiation and progression have not yet been fully explored. Long intragenic non-coding RNA p53-induced transcript (LINC-PINT) is an lncRNA that functions as a tumor suppressor gene involved in various tumors and malignant activities. LINC-PINT is downregulated in nasopharyngeal cancer, renal carcinoma, non-small cell lung cancer, glioblastoma, thyroid cancer, retinoblastoma, ovarian cancer, breast cancer, esophageal squamous cell carcinoma, osteosarcoma, melanoma, and gastric cancer. Furthermore, decreased LINC-PINT expression predicts poor prognosis and advanced clinical tumor stages. Together, these studies indicate that LINC-PINT could serve as a diagnostic and prognostic indicator in cancer. The specific lncRNA regulatory mechanism of LINC-PINT may also be a novel target for cancer therapies.
癌症涉及复杂的病因、多个阶段和复杂的基因突变。长链非编码RNA（lncRNA）被认为是各种生理和病理生理条件下人类基因组活动的分子机制。然而，将lncRNA与癌症发生和进展联系起来的复杂修饰和调控过程尚未得到充分探索。长基因内非编码RNA p53诱导转录本（LINC-PINT）是一种lncRNA，作为一种肿瘤抑制基因，参与各种肿瘤和恶性活动。LINC-PINT在鼻咽癌、肾癌、非小细胞肺癌、胶质母细胞瘤、甲状腺癌、视网膜母细胞瘤、卵巢癌、乳腺癌、食管鳞状细胞癌、骨肉瘤、黑色素瘤和胃癌中表达下调。此外，LINC-PINT表达降低预示着预后不良和临床肿瘤分期较晚。总之，这些研究表明LINC-PINT可作为癌症的诊断和预后指标。LINC-PINT的特定lncRNA调控机制也可能是癌症治疗的新靶点。
