Henan Key Laboratory of Helicobacter pylori, Microbiota and Gastrointestinal Cancer, Marshall Medical Research Center, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Gastroenterology, Fifth Affiliated hospital of Zhengzhou University, Zhengzhou, China.
Wiley Interdiscip Rev RNA. 2022 Jul;13(4):e1705. doi: 10.1002/wrna.1705. Epub 2022 Jan 12.
LINC-PINT is a p53-induced long intergenic noncoding transcript that plays a crucial role in many diseases, especially cancer. This long noncoding RNA (lncRNA) gene produces in total 102 (LNCipedia) alternatively spliced variants (LINC-PINT:1 to LINC-PINT:102). The functions of known variants include RNA transcripts, host transcripts for circular RNA (circRNA) generation and as sources for the translation of short peptides. In most human tumors, LINC-PINT is down-regulated where it serves as a tumor suppressor. However, the diversity of its functions in other maladies signifies its general clinical importance. Current LINC-PINT molecular functions include RNA-protein interactions, miRNA sponging and epigenetic modulation with these mechanisms operating in different cellular contexts to exert effects on biological processes ranging from DNA damage responses, cell cycle and growth arrest, senescence, cell migration and invasion, and apoptosis. Genetic polymorphisms in LINC-PINT have also been functionally associated with cancer and other pathologies including the autoimmune diseases pemphigus foliaceus and arthritis. Hence, LINC-PINT shows great potential as a clinical biomarker, especially for the diagnosis and prognosis of cancer. In this review, we explore the current knowledge highlighting the distinctive molecular functions of LINC-PINT in specific cancers and other disease states. This article is categorized under: RNA in Disease and Development > RNA in Disease.
LINC-PINT 是一种 p53 诱导的长基因间非编码转录本，在许多疾病中发挥着至关重要的作用，尤其是癌症。这种长非编码 RNA（lncRNA）基因总共产生 102 种（LNCipedia）可变剪接变体（LINC-PINT：1 至 LINC-PINT：102）。已知变体的功能包括 RNA 转录物、环状 RNA（circRNA）生成的宿主转录物以及翻译短肽的来源。在大多数人类肿瘤中，LINC-PINT 下调，起到肿瘤抑制因子的作用。然而，其在其他疾病中的功能多样性表明其具有普遍的临床重要性。目前 LINC-PINT 的分子功能包括 RNA-蛋白质相互作用、miRNA 海绵作用和表观遗传调节，这些机制在不同的细胞环境中发挥作用，对从 DNA 损伤反应、细胞周期和生长停滞、衰老、细胞迁移和侵袭以及细胞凋亡等生物学过程产生影响。LINC-PINT 的遗传多态性也与癌症和其他病理学（包括自身免疫性疾病天疱疮和关节炎）的功能相关。因此，LINC-PINT 具有作为临床生物标志物的巨大潜力，特别是用于癌症的诊断和预后。在这篇综述中，我们探讨了目前的知识，强调了 LINC-PINT 在特定癌症和其他疾病状态下的独特分子功能。本文属于以下分类：RNA 在疾病与发育中的作用 > RNA 在疾病中的作用。
