研究 COVID-19 患者的 HLA-A、-B、-C、-DRB1 和 -DQB1 多态性。
Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients.
机构信息
Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de Las Nieves, Granada, Spain; Programa de Doctorado en Biomedicina, University of Granada, Spain.
Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de Las Nieves, Granada, Spain.
出版信息
J Microbiol Immunol Infect. 2022 Jun;55(3):421-427. doi: 10.1016/j.jmii.2021.08.009. Epub 2021 Aug 25.
Abstract
BACKGROUND
Human leukocyte antigen (HLA) plays an important role in immune responses to infections, especially in the development of acquired immunity. Given the high degree of polymorphisms that HLA molecules present, some will be more or less effective in controlling SARS-CoV-2 infection. We wanted to analyze whether certain polymorphisms may be involved in the protection or susceptibility to COVID-19.
METHODS
We studied the polymorphisms in HLA class I (HLA-A, -B and -C) and II (HLA-DRB1 and HLA-DQB1) molecules in 450 patients who required hospitalization for COVID-19, creating one of the largest HLA-typed patient cohort to date.
RESULTS
Our results show that there is no relationship between HLA polymorphisms or haplotypes and susceptibility or protection to COVID-19.
CONCLUSION
Our results may contribute to resolve the contradictory data on the role of HLA polymorphisms in COVID-19 infection.
摘要
背景
人类白细胞抗原（HLA）在免疫应对感染方面发挥着重要作用，尤其是在获得性免疫的发展方面。鉴于 HLA 分子具有高度多态性，某些分子在控制 SARS-CoV-2 感染方面可能或多或少地有效。我们希望分析某些多态性是否可能与 COVID-19 的保护或易感性有关。
方法
我们研究了 450 名因 COVID-19 而需要住院的患者中 HLA Ⅰ类（HLA-A、-B 和 -C）和 II 类（HLA-DRB1 和 HLA-DQB1）分子的多态性，创建了迄今为止最大的 HLA 分型患者队列之一。
结果
我们的结果表明，HLA 多态性或单倍型与 COVID-19 的易感性或保护之间没有关系。
结论
我们的结果可能有助于解决 HLA 多态性在 COVID-19 感染中的作用的矛盾数据。
相似文献
1
Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients.研究 COVID-19 患者的 HLA-A、-B、-C、-DRB1 和 -DQB1 多态性。
J Microbiol Immunol Infect. 2022 Jun;55(3):421-427. doi: 10.1016/j.jmii.2021.08.009. Epub 2021 Aug 25.
2
[Establishment and validation of prediction models for human leukocyte antigen haplotypes and human leukocyte antigen genotypes].[人类白细胞抗原单倍型和人类白细胞抗原基因型预测模型的建立与验证]
Zhonghua Yi Xue Za Zhi. 2024 Mar 19;104(11):834-842. doi: 10.3760/cma.j.cn112137-20231130-01246.
3
Study on the polymorphisms of HLA-ABCDQB1DRB1 alleles and haplotypes in Hubei Han population of China.中国湖北汉族人群 HLA-ABCDQB1DRB1 等位基因和单倍型多态性研究。
Int J Immunogenet. 2021 Feb;48(1):8-15. doi: 10.1111/iji.12516. Epub 2020 Sep 29.
4
Human Leukocyte Antigen Complex and Other Immunogenetic and Clinical Factors Influence Susceptibility or Protection to SARS-CoV-2 Infection and Severity of the Disease Course. The Sardinian Experience.人类白细胞抗原复合体和其他免疫遗传及临床因素影响对 SARS-CoV-2 感染的易感性或保护作用，以及疾病过程的严重程度。撒丁岛的经验。
Front Immunol. 2020 Dec 4;11:605688. doi: 10.3389/fimmu.2020.605688. eCollection 2020.
5
Distribution of HLA-A, -C, -B, -DRB1, and -DQB1 polymorphisms in the Korean minority in Kazakhstan, and relatedness to neighboring and distant populations.哈萨克斯坦朝鲜族人群 HLA-A、-C、-B、-DRB1 和 -DQB1 多态性分布及与邻近和远距离人群的相关性。
Gene. 2022 May 20;823:146386. doi: 10.1016/j.gene.2022.146386. Epub 2022 Mar 3.
6
HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China.中国南方汉族人群的HLA I类（A、B、C）和II类（DRB1、DQA1、DQB1、DPB1）等位基因及单倍型
Tissue Antigens. 2007 Dec;70(6):455-63. doi: 10.1111/j.1399-0039.2007.00932.x. Epub 2007 Sep 27.
7
Investigation of HLA susceptibility alleles and genotypes with hematological disease among Chinese Han population.中国汉族人群血液系统疾病与 HLA 易感性等位基因和基因型的研究。
PLoS One. 2024 Apr 9;19(4):e0281698. doi: 10.1371/journal.pone.0281698. eCollection 2024.
8
[Study of polymorphisms of HLA class Ⅰ (-A, -B, -C) and class Ⅱ (DRB1, DQA1, DQB1, DPA1, DPB1) genes among ethnic Hans from Southern China].中国南方汉族人群 HLA Ⅰ类（-A、-B、-C）和Ⅱ类（DRB1、DQA1、DQB1、DPA1、DPB1）基因多态性研究
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017 Feb 10;34(1):110-114. doi: 10.3760/cma.j.issn.1003-9406.2017.01.026.
9
HLA Alleles, Genotype and Haplotype Analyzes from Central Anatolia Region of Turkey.土耳其安纳托利亚中部地区的 HLA 等位基因、基因型和单倍型分析。
Balkan Med J. 2023 Sep 11;40(5):358-366. doi: 10.4274/balkanmedj.galenos.2023.2023-4-55. Epub 2023 Aug 16.
10
Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese population.日本人群中通过HLA I类和II类基因座的等位基因DNA分型定义的等位基因频率和单倍型关联。
Tissue Antigens. 2000 Dec;56(6):522-9. doi: 10.1034/j.1399-0039.2000.560606.x.
引用本文的文献
1
Investigation of -21 M/T Dimorphism and Its Potential Role in COVID-19.-21 M/T 二态性及其在 COVID-19 中的潜在作用研究。
Int J Mol Sci. 2025 Jul 3;26(13):6419. doi: 10.3390/ijms26136419.
2
Influence of HLA Class I and II Polymorphisms on COVID-19 Severity in a South Brazilian Population.巴西南部人群中 HLA Ⅰ类和Ⅱ类多态性对 COVID-19 严重程度的影响
Int J Mol Sci. 2025 Jun 2;26(11):5341. doi: 10.3390/ijms26115341.
3
HLA Polymorphisms and COVID-19 Susceptibility and Severity: Insights From an Iranian Patients Cohort.HLA多态性与COVID-19易感性及严重程度：来自伊朗患者队列的见解
J Cell Mol Med. 2025 May;29(9):e70570. doi: 10.1111/jcmm.70570.
4
Association between HLA genetics and SARS-CoV-2 infection in a large real-world cohort.大型真实世界队列中HLA基因与SARS-CoV-2感染之间的关联
Genes Immun. 2025 Apr 24. doi: 10.1038/s41435-025-00328-4.
5
Rare peptide anchors of HLA class I alleles contribute to the COVID-19 disease severity and T cell memory.人类白细胞抗原I类等位基因的罕见肽锚定物会影响新冠疾病的严重程度和T细胞记忆。
Biosaf Health. 2023 Sep 14;5(6):355-362. doi: 10.1016/j.bsheal.2023.09.002. eCollection 2023 Dec.
6
The HLA-B -21 M/T dimorphism associates with disease severity in COVID-19.人类白细胞抗原B-21 M/T二态性与新冠病毒疾病严重程度相关。
Genes Immun. 2025 Feb;26(1):70-74. doi: 10.1038/s41435-024-00302-6. Epub 2024 Nov 1.
7
Association of Human Leukocyte Antigen Alleles with COVID-19 Severity and Mortality in a Spanish Population.人类白细胞抗原等位基因与西班牙人群中 COVID-19 严重程度和死亡率的关联。
Medicina (Kaunas). 2024 Aug 25;60(9):1392. doi: 10.3390/medicina60091392.
8
Narrative Review Explaining the Role of , , and Molecules in COVID-19 Disease in and around Africa.叙述性综述：解释、和分子在非洲及周边地区COVID-19疾病中的作用
Infect Dis Rep. 2024 Apr 18;16(2):380-406. doi: 10.3390/idr16020029.
9
Evaluation the frequencies of HLA alleles in moderate and severe COVID-19 patients in Iran: A molecular HLA typing study.评估伊朗中重度新冠肺炎患者的HLA等位基因频率：一项HLA分子分型研究。
Heliyon. 2024 Mar 26;10(7):e28528. doi: 10.1016/j.heliyon.2024.e28528. eCollection 2024 Apr 15.
10
Influence of HLA-A, -B, -DR Polymorphisms on the Severity of COVID-19: A Case-Control Study in the Iranian Population.HLA-A、-B、-DR 多态性对 COVID-19 严重程度的影响：伊朗人群的病例对照研究。
Arch Iran Med. 2023 May 1;26(5):261-266. doi: 10.34172/aim.2023.40.
本文引用的文献
1
HLA genetic polymorphisms and prognosis of patients with COVID-19.HLA基因多态性与新型冠状病毒肺炎患者的预后
Med Intensiva. 2021 Mar;45(2):96-103. doi: 10.1016/j.medin.2020.08.004. Epub 2020 Sep 6.
2
MHC Haplotyping of SARS-CoV-2 Patients: HLA Subtypes Are Not Associated with the Presence and Severity of COVID-19 in the Israeli Population.对 SARS-CoV-2 患者的 MHC 单体型分析：在以色列人群中，HLA 亚型与 COVID-19 的存在和严重程度无关。
J Clin Immunol. 2021 Aug;41(6):1154-1161. doi: 10.1007/s10875-021-01071-x. Epub 2021 May 29.
3
Human Leukocyte Antigen (HLA) Class I Susceptible Alleles Against COVID-19 Increase Both Infection and Severity Rate.人类白细胞抗原（HLA）I类抗新冠病毒易感性等位基因会增加感染率和重症率。
Cureus. 2020 Dec 23;12(12):e12239. doi: 10.7759/cureus.12239.
4
Human Leukocyte Antigen Complex and Other Immunogenetic and Clinical Factors Influence Susceptibility or Protection to SARS-CoV-2 Infection and Severity of the Disease Course. The Sardinian Experience.人类白细胞抗原复合体和其他免疫遗传及临床因素影响对 SARS-CoV-2 感染的易感性或保护作用，以及疾病过程的严重程度。撒丁岛的经验。
Front Immunol. 2020 Dec 4;11:605688. doi: 10.3389/fimmu.2020.605688. eCollection 2020.
5
Negative Clinical Evolution in COVID-19 Patients Is Frequently Accompanied With an Increased Proportion of Undifferentiated Th Cells and a Strong Underrepresentation of the Th1 Subset.在 COVID-19 患者中，临床病情恶化常伴随着未分化 Th 细胞比例增加和 Th1 亚群明显减少。
Front Immunol. 2020 Nov 26;11:596553. doi: 10.3389/fimmu.2020.596553. eCollection 2020.
6
Genetic mechanisms of critical illness in COVID-19.新型冠状病毒肺炎危重症的遗传机制。
Nature. 2021 Mar;591(7848):92-98. doi: 10.1038/s41586-020-03065-y. Epub 2020 Dec 11.
7
Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility.宿主基因对新冠病毒疾病严重程度和易感性影响的全基因组初步测序与分析
Cell Discov. 2020 Nov 10;6(1):83. doi: 10.1038/s41421-020-00231-4.
8
Population Difference in Allele Frequency of HLA-C*05 and Its Correlation with COVID-19 Mortality.人群中 HLA-C*05 等位基因频率的差异及其与 COVID-19 死亡率的关系。
Viruses. 2020 Nov 20;12(11):1333. doi: 10.3390/v12111333.
9
Clinical, regional, and genetic characteristics of Covid-19 patients from UK Biobank.英国生物银行新冠患者的临床、区域和遗传特征。
PLoS One. 2020 Nov 17;15(11):e0241264. doi: 10.1371/journal.pone.0241264. eCollection 2020.
10
Association of HLA-B22 serotype with SARS-CoV-2 susceptibility in Hong Kong Chinese patients.HLA-B22 血清型与香港华裔 SARS-CoV-2 易感性的关联。
HLA. 2021 Feb;97(2):127-132. doi: 10.1111/tan.14135. Epub 2020 Dec 1.
Zotero 插件