Croton R, Cooke T, Holt S, George W D, Nicolson R, Griffiths K
Br Med J (Clin Res Ed). 1981 Nov 14;283(6302):1289-91. doi: 10.1136/bmj.283.6302.1289.
Oestrogen receptor status was related to survival in 414 patients with primary breast cancer. Women with oestrogen receptors in their tumours survived significantly longer than those without receptors; this was true for both premenopausal and postmenopausal women and also when the patients were subdivided into those with and without axillary metastases. Patients with axillary metastases and no oestrogen receptors in their tumours had the worst prognosis, while women with axillary metastases and oestrogen receptors had a death rate similar to that of women with no axillary metastases and no receptors. Patients without oestrogen receptors and with no axillary metastases were identified as a high-risk group, and it would seem appropriate to include such patients in future trials for adjuvant therapy in early breast cancer.
雌激素受体状态与414例原发性乳腺癌患者的生存情况相关。肿瘤中有雌激素受体的女性患者的存活时间明显长于没有受体的患者；绝经前和绝经后女性均如此，而且当将患者分为有腋窝转移和无腋窝转移两组时也是如此。肿瘤中无雌激素受体且有腋窝转移的患者预后最差，而有腋窝转移且有雌激素受体的女性患者的死亡率与无腋窝转移且无受体的女性患者相似。无雌激素受体且无腋窝转移的患者被确定为高危组，在未来早期乳腺癌辅助治疗试验中纳入这类患者似乎是合适的。
