Romani A, Merello S, Gozzoli L, Zerbi F, Grassi M, Cosi V
C. Mondino Institute, Neurological Clinic, Pavia, Italy.
Br J Psychiatry. 1987 Oct;151:506-13. doi: 10.1192/bjp.151.4.506.
Twenty chronic male schizophrenic subjects aged 30-50 years were examined by an auditory event-related potential procedure for the evaluation of the P300 component, a CT scan and a neuropsychological test battery. The P300 latency was increased and its amplitude was reduced. CT scan measures showed lateral and third ventricle enlargement, and there was a global neuropsychological impairment. Poor neuropsychological performances were consistently associated with delayed P300 latencies, but not with CT scan measures. Ventricular enlargement was more pronounced among subjects with a negative family history for major psychiatric disorders.
对20名年龄在30至50岁之间的慢性男性精神分裂症患者进行了听觉事件相关电位检查，以评估P300成分，还进行了CT扫描和一套神经心理学测试。结果显示P300潜伏期延长，波幅降低。CT扫描测量显示侧脑室和第三脑室扩大，并且存在整体神经心理学损害。神经心理学表现不佳始终与P300潜伏期延迟相关，但与CT扫描测量结果无关。在有严重精神疾病阴性家族史的受试者中，脑室扩大更为明显。
