Ghafouri-Fard Soudeh, Abak Atefe, Talebi Seyedeh Fahimeh, Shoorei Hamed, Branicki Wojciech, Taheri Mohammad, Akbari Dilmaghani Nader
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Biomed Pharmacother. 2021 Nov;143:112132. doi: 10.1016/j.biopha.2021.112132. Epub 2021 Sep 1.
Fibrosis is the endpoint of pathological remodeling. This process contributes to the pathogenesis of several chronic disorders and aging-associated organ damage. Different molecular cascades contribute to this process. TGF-β, WNT, and YAP/TAZ signaling pathways have prominent roles in this process. A number of long non-coding RNAs and microRNAs have been found to regulate organ fibrosis through modulation of the activity of related signaling pathways. miR-144-3p, miR-451, miR-200b, and miR-328 are among microRNAs that participate in the pathology of cardiac fibrosis. Meanwhile, miR-34a, miR-17-5p, miR-122, miR-146a, and miR-350 contribute to liver fibrosis in different situations. PVT1, MALAT1, GAS5, NRON, PFL, MIAT, HULC, ANRIL, and H19 are among long non-coding RNAs that participate in organ fibrosis. We review the impact of long non-coding RNAs and microRNAs in organ fibrosis and aging-related pathologies.
纤维化是病理性重塑的终点。这一过程促成了多种慢性疾病的发病机制以及与衰老相关的器官损伤。不同的分子级联反应参与了这一过程。转化生长因子-β（TGF-β）、WNT和YAP/TAZ信号通路在这一过程中发挥着重要作用。已发现许多长链非编码RNA和微小RNA通过调节相关信号通路的活性来调控器官纤维化。miR-144-3p、miR-451、miR-200b和miR-328是参与心脏纤维化病理过程的微小RNA。同时，miR-34a、miR-17-5p、miR-122、miR-146a和miR-350在不同情况下促成肝纤维化。PVT1、MALAT1、GAS5、NRON、PFL、MIAT、HULC、ANRIL和H19是参与器官纤维化的长链非编码RNA。我们综述了长链非编码RNA和微小RNA在器官纤维化及衰老相关病理中的影响。
