血清 CXCL10/IP-10 可能是儿童严重肺炎支原体肺炎的潜在生物标志物。
Serum CXCL10/IP-10 may be a potential biomarker for severe Mycoplasma pneumoniae pneumonia in children.
机构信息
Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Department of Pediatrics, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
出版信息
BMC Infect Dis. 2021 Sep 4;21(1):909. doi: 10.1186/s12879-021-06632-4.
BACKGROUND
How to early distinguish the severity of Mycoplasma pneumoniae pneumonia (MPP) is a worldwide concern in clinical practice. We therefore conducted this study to assess the relationship between levels of serum inflammatory chemokines and the severity of MPP.
METHODS
In this prospective study, we enrolled 39 children with MPP, whose clinical information was collected, blood samples were assayed for cytokines and chemokines by ELISA.
RESULTS
The levels of serum CXCL10 in children with severe MPP were significantly higher than those in children with mild MPP (2500.0 [1580.9-2500.0] vs. 675.7 [394.7-1134.9], P < 0.001). Measurement of CXCL10 levels in serum enabled the differentiation of children with severe MPP with an area under the curve (AUC) of 0.885 (95 % CI 0.779-0.991, P < 0.001), with a sensitivity of 81.0 % and a specificity of 83.3 %.
CONCLUSIONS
Serum CXCL10 level may be a potential biomarker for severe MPP in children.
背景
如何早期区分肺炎支原体肺炎（MPP）的严重程度是临床实践中的全球性关注问题。因此，我们进行了这项研究，以评估血清炎症趋化因子水平与 MPP 严重程度之间的关系。
方法
在这项前瞻性研究中，我们纳入了 39 例患有 MPP 的儿童，收集了他们的临床信息，并通过 ELISA 检测了血液样本中的细胞因子和趋化因子。
结果
严重 MPP 患儿血清中 CXCL10 的水平明显高于轻度 MPP 患儿（2500.0 [1580.9-2500.0] 比 675.7 [394.7-1134.9]，P<0.001）。测量血清中 CXCL10 的水平能够区分严重 MPP 患儿，曲线下面积（AUC）为 0.885（95%CI 0.779-0.991，P<0.001），敏感性为 81.0%，特异性为 83.3%。
结论
血清 CXCL10 水平可能是儿童严重 MPP 的潜在生物标志物。
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