Department of Exact and Natural Sciences, Universidad de la Costa, Calle 58#55-66, Barranquilla, Colombia.
Engineering Faculty, Universidad Libre Barranquilla, Cra 46 No. 48-170, Barranquilla, Colombia.
Environ Pollut. 2021 Dec 1;290:118037. doi: 10.1016/j.envpol.2021.118037. Epub 2021 Aug 30.
Landfills, as well as other waste management facilities are well-known bioaerosols sources. These places may foment antibiotic-resistance in bacterial bioaerosol (A.R.B.) due to inadequate pharmaceutical waste disposal. This issue may foster the necessity of using last-generation antibiotics with extra costs in the health care system, and deaths. The aim of this study was to reveal the multi-antibiotic resistant bacterial bioaerosol emitted by a sanitary landfill and the surrounding area. We evaluated the influence of environmental conditions in the occurrence of A.R.B. and biological risk assessment. Antibiotic resistance found in the bacteria aerosols was compared with the AWaRE consumption classification. We used the BIOGAVAL method to assess the workers' occupational exposure to antibiotic-resistant bacterial bioaerosols in the landfill. This study confirmed the multi-antibiotic resistant in bacterial bioaerosol in a landfill and in the surrounding area. Obtained mean concentrations of bacterial bioaerosols, as well as antibiotic-resistant in bacterial bioaerosol (A.R.B.), were high, especially for fine particles that may be a threat for human health. Results suggest the possible risk of antibiotic-resistance interchange between pathogenic and non-pathogenic species in the landfill facilities, thus promoting antibiotic multi-resistance genes spreading into the environment.
垃圾填埋场以及其他废物管理设施是众所周知的生物气溶胶来源。由于药物废物处理不当，这些地方可能会助长细菌生物气溶胶（ARB）中的抗生素耐药性。这个问题可能会促使医疗保健系统需要使用具有额外成本的新一代抗生素，从而导致更多的死亡。本研究的目的是揭示卫生填埋场及其周围环境中排放的多抗生素耐药细菌生物气溶胶。我们评估了环境条件对ARB 发生的影响以及生物风险评估。对细菌气溶胶中发现的抗生素耐药性与 AWaRE 消费分类进行了比较。我们使用 BIOGAVAL 方法评估了工人在垃圾填埋场中接触抗生素耐药细菌生物气溶胶的职业暴露情况。这项研究证实了垃圾填埋场及其周围环境中细菌生物气溶胶的多抗生素耐药性。获得的细菌生物气溶胶以及细菌生物气溶胶（ARB）中的抗生素耐药性的平均浓度很高，尤其是对于细小颗粒，这些颗粒可能对人体健康构成威胁。研究结果表明，在垃圾填埋场设施中，病原体和非病原体之间的抗生素耐药性可能存在交叉交换的风险，从而促进抗生素多耐药基因向环境中的传播。
